重度抑郁症患者与终末期肾病患者的生活质量及抑郁症状：一项配对研究。
Quality of life and depressive symptoms in patients with major depression and end-stage renal disease: a matched-pair study.
作者信息
Berlim Marcelo T, Mattevi Betina S, Duarte Anne Paola G, Thomé Fernando S, Barros Elvino J G, Fleck Marcelo P
机构信息
Department of Psychiatry and Forensic Medicine, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
出版信息
J Psychosom Res. 2006 Nov;61(5):731-4. doi: 10.1016/j.jpsychores.2006.04.011.
OBJECTIVE
To compare the quality of life (QOL) and depressive symptoms of outpatients with major depression with that of nondepressed individuals undergoing hemodialysis (matched for age, gender, and ethnicity).
METHODS
We used the WHOQOL BREF and the Beck Depression Inventory (BDI).
RESULTS
After univariate analyses, depressed patients' QOL scores were significantly lower (P<.0001) in all the assessed domains (i.e., physical health, psychological, social relationships, environmental, and global QOL). Additionally, there was a significant difference in the severity of depression among the study groups (P<.0001). Finally, after multiple regression analysis, the QOL profile of depressed subjects remained significantly worse even when controlling for depression scores and diagnostic status.
CONCLUSION
The subjective QOL of patients with major depression is significantly lower than that of subjects undergoing hemodialysis.
目的
比较重度抑郁症门诊患者与接受血液透析的非抑郁症患者（年龄、性别和种族匹配）的生活质量（QOL）和抑郁症状。
方法
我们使用了世界卫生组织生活质量简表（WHOQOL BREF）和贝克抑郁量表（BDI）。
结果
单因素分析后，抑郁症患者在所有评估领域（即身体健康、心理、社会关系、环境和总体生活质量）的生活质量得分均显著较低（P<.0001）。此外，研究组之间抑郁严重程度存在显著差异（P<.0001）。最后，多元回归分析后，即使控制抑郁得分和诊断状态，抑郁症患者的生活质量概况仍显著较差。
结论
重度抑郁症患者的主观生活质量显著低于接受血液透析的患者。
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