Zhang L, Jin X M, He Y, Chi J M, Ban X, Huang Q
Department of Pathology, Harbin Medical University, Harbin, Heilongjiang Province, 150086, China.
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2006 Sep;20(3):247-9.
To explore the relationship between hepatitis B virus (HBV) infection and development of IgA nephropathy.
HBsAg and HBcAg protein in renal biopsy specimens of 32 cases was detected on frozen sections and HBV DNA was detected in paraffin section of renal biopsies and in serum of 42 HBsAg positive cases.
The positive rate of HBAg in renal biopsies of IgA nephropathy was 59.1%, and 63.6% in non-IgA nephropathy, there was no significant difference between them. In 42 cases biopsies of renal tissues, only five were HBV-DNA positive (11.9%). The five cases were HBsAg, HBcAb and HBeAg positive, the pathological diagnosis of two cases were mesangial proliferative glomerulonephritis; one had minimal change of glomerulonephritis; and one had basement membrane change; and only one had IgA nephropathy. At the same time, in 42 HBsAg+ cases the serum specimens were detected; 12 cases were positive for HBsAg, HBcAg and HBeAg, in whom serum HBV-DNA was positive, but only 5 were positive for HBV-DNA in renal biopsy tissue, and HBV-DNA was negative in other 30 blood serum and tissue specimens.
The difference in expression of HBsAg, HBcAb and HBeAg protein between IgA nephropathy and non-IgA nephropathy tissue from renal biopsy was not significant. There is no direct relationship between HBV infection and IgA nephropathy.
探讨乙型肝炎病毒（HBV）感染与IgA肾病发生发展之间的关系。
对32例肾活检标本的冰冻切片进行HBsAg和HBcAg蛋白检测，并对42例HBsAg阳性患者的肾活检石蜡切片及血清进行HBV DNA检测。
IgA肾病肾活检中HBAg阳性率为59.1%，非IgA肾病为63.6%，两者差异无统计学意义。42例肾组织活检中，仅5例HBV-DNA阳性（11.9%）。这5例患者HBsAg、HBcAb及HBeAg均阳性，其中2例病理诊断为系膜增生性肾小球肾炎；1例为轻微病变性肾小球肾炎；1例有基底膜改变；仅1例为IgA肾病。同时，对42例HBsAg阳性患者血清标本进行检测，12例HBsAg、HBcAg及HBeAg阳性，其血清HBV-DNA阳性，但肾活检组织中仅5例HBV-DNA阳性，其余30例血清及组织标本HBV-DNA均为阴性。
肾活检中IgA肾病与非IgA肾病组织HBsAg、HBcAb及HBeAg蛋白表达差异无统计学意义。HBV感染与IgA肾病无直接关系。
