Rosenberg G A, Estrada E, Wesley M, Kyner W T
Department of Neurology, University of New Mexico, Albuquerque.
Acta Neurochir Suppl (Wien). 1990;51:280-2. doi: 10.1007/978-3-7091-9115-6_95.
Cerebral oedema accompanies intracerebral haemorrhage. We induced intracranial bleeding by the intracerebral injection of bacterial collagenase. There was oedema observed both at the haematoma site in the caudate/putamen and bilaterally in the hippocampal regions. To determine the role of vasogenic oedema spread from the site of injury, we studied by autoradiography the distribution of extracellular markers injected along with the collagenase. Both 14C-dextran (m.w. 70,000) and 14C-sucrose (m.w. 341) spread away from the injection site into both hippocampal regions in a similar pattern, suggesting bulk flow. Vasogenic oedema secondary to a haemorrhagic lesion in the caudate/putamen is an important cause of the oedema observed in both hippocampal regions in our model.
脑水肿伴随脑内出血出现。我们通过脑内注射细菌胶原酶诱导颅内出血。在尾状核/壳核的血肿部位以及双侧海马区均观察到了水肿。为了确定损伤部位产生的血管源性水肿扩散的作用，我们通过放射自显影术研究了与胶原酶一起注射的细胞外标记物的分布。14C-葡聚糖（分子量70,000）和14C-蔗糖（分子量341）均以相似的模式从注射部位扩散到双侧海马区，提示存在大量流动。在我们的模型中，尾状核/壳核出血性病变继发的血管源性水肿是双侧海马区观察到的水肿的重要原因。
