基于体素的形态测量法揭示酒精成瘾患者中广泛存在的独特脑萎缩模式。
A widespread distinct pattern of cerebral atrophy in patients with alcohol addiction revealed by voxel-based morphometry.
作者信息
Mechtcheriakov Sergei, Brenneis Christian, Egger Karl, Koppelstaetter Florian, Schocke Michael, Marksteiner Josef
机构信息
Department of General Psychiatry, Medical University Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria.
出版信息
J Neurol Neurosurg Psychiatry. 2007 Jun;78(6):610-4. doi: 10.1136/jnnp.2006.095869. Epub 2006 Nov 6.
BACKGROUND
Patients with alcohol addiction show a number of transient or persistent neurological and psychiatric deficits. The complexity of these brain alterations suggests that several brain areas are involved, although the definition of the brain alteration patterns is not yet accomplished.
AIM
To determine brain atrophy patterns in patients with alcohol dependence.
METHODS
Voxel-based morphometry (VBM) of grey matter (GM) and white matter (WM) was performed in 22 patients with alcohol dependence and in 22 healthy controls matched for age and sex.
RESULTS
In patients with alcohol dependence, VBM of GM revealed a significant decrease in density (p<0.001) in the precentral gyrus, middle frontal gyrus, insular cortex, dorsal hippocampus, anterior thalamus and cerebellum compared with controls. Reduced density of WM was found in the periventricular area, pons and cerebellar pedunculi in patients with alcohol addiction.
CONCLUSIONS
Our findings provide evidence that alcohol addiction is associated with altered density of GM and WM of specific brain regions. This supports the assumption that alcohol dependence is associated with both local GM dysfunction and altered brain connectivity. Also, VBM is an effective tool for in vivo investigation of cerebral atrophy in patients with alcohol addiction.
背景
酒精成瘾患者表现出一些短暂或持续的神经和精神缺陷。这些大脑改变的复杂性表明有多个脑区参与其中，尽管大脑改变模式的定义尚未完成。
目的
确定酒精依赖患者的脑萎缩模式。
方法
对22例酒精依赖患者和22名年龄及性别匹配的健康对照者进行基于体素的形态学测量（VBM），以检测灰质（GM）和白质（WM）。
结果
与对照组相比，酒精依赖患者的GM的VBM显示中央前回、额中回、岛叶皮质、背侧海马、前丘脑和小脑的密度显著降低（p<0.001）。酒精成瘾患者的脑室周围区域、脑桥和小脑脚的WM密度降低。
结论
我们的研究结果证明，酒精成瘾与特定脑区GM和WM的密度改变有关。这支持了酒精依赖与局部GM功能障碍和脑连接改变均有关的假设。此外，VBM是对酒精成瘾患者脑萎缩进行体内研究的有效工具。
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