Nabhan Zeina M, Eugster Erica A
Section of Pediatric Endocrinology, Department of Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
Pediatrics. 2006 Dec;118(6):e1900-3. doi: 10.1542/peds.2006-0955. Epub 2006 Nov 6.
Monozygotic twins with Turner syndrome have rarely been reported. An increased incidence of slipped capital femoral epiphysis has been associated with growth hormone therapy, as well as with Turner syndrome, but has never been described in twins with Turner syndrome. We report the first case of monozygotic twins with Turner syndrome with a 46,Xi(Xq) karyotype, both of whom developed slipped capital femoral epiphysis during growth hormone therapy. This report adds to existing reports of monozygotic twins with Turner syndrome and contributes to recognition of the potential clinical course in such patients. In addition, the association between slipped capital femoral epiphysis, growth hormone therapy, and Turner syndrome is emphasized.
关于患有特纳综合征的单卵双胞胎的报道极为罕见。股骨头骨骺滑脱的发病率增加与生长激素治疗以及特纳综合征有关，但从未在患有特纳综合征的双胞胎中被描述过。我们报告了首例核型为46,Xi(Xq)的患有特纳综合征的单卵双胞胎，她们在生长激素治疗期间均发生了股骨头骨骺滑脱。本报告补充了现有的关于患有特纳综合征的单卵双胞胎的报道，并有助于认识此类患者可能的临床病程。此外，强调了股骨头骨骺滑脱、生长激素治疗和特纳综合征之间的关联。
