FGFR4基因多态性与TP53基因突变联合对膀胱癌预后的影响
Joint association of polymorphism of the FGFR4 gene and mutation TP53 gene with bladder cancer prognosis.
作者信息
Yang Y C, Lu M L, Rao J Y, Wallerand H, Cai L, Cao W, Pantuck A, Dalbagni G, Reuter V, Figlin R A, Belldegrun A, Cordon-Cardo C, Zhang Z F
机构信息
Department of Epidemiology, UCLA School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, CA 90095, USA.
出版信息
Br J Cancer. 2006 Dec 4;95(11):1455-8. doi: 10.1038/sj.bjc.6603456. Epub 2006 Nov 7.
The impact of the fibroblast growth factor receptor 4 (FGFR4) Gly388Arg polymorphism on bladder cancer is unknown. We found no clear correlations between the FGFR4 genotype and risk of bladder cancer or pathological parameters. Neither the polymorphism nor TP53 mutation status was an independent predictor of prognosis, but they might act jointly on the disease-specific survival of patients.
成纤维细胞生长因子受体4（FGFR4）Gly388Arg多态性对膀胱癌的影响尚不清楚。我们发现FGFR4基因型与膀胱癌风险或病理参数之间没有明显的相关性。该多态性和TP53突变状态均不是预后的独立预测因素，但它们可能共同影响患者的疾病特异性生存。
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