Hayward G S, Zong J C
Viral Oncology Program, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, MD 21231, USA.
Curr Top Microbiol Immunol. 2007;312:1-42. doi: 10.1007/978-3-540-34344-8_1.
The genomes of several human herpesviruses, including Kaposi sarcoma (KS) herpesvirus (KSHV), display surprisingly high levels of both genetic diversity and clustered subtyping at certain loci. We have been interested in understanding this phenomenon with the hope that it might be a useful diagnostic tool for viral epidemiology, and that it might provide some insights about how these large viral genomes evolve over a relatively short timescale. To do so, we have carried out extensive PCR DNA sequence analysis across the genomes of 200 distinct KSHV samples collected from KS patients around the world. Here we review and summarize current understanding of the origins of KSHV variability, the spread of KSHV and its human hosts out of Africa, the existence of chimeric genomes, and the concept that different segments of the genome have had different evolutionary histories.
包括卡波西肉瘤相关疱疹病毒（KSHV）在内的几种人类疱疹病毒的基因组，在某些位点显示出惊人的高遗传多样性水平和聚类亚型。我们一直致力于理解这一现象，希望它可能成为病毒流行病学的有用诊断工具，并可能为这些大型病毒基因组如何在相对较短的时间尺度上进化提供一些见解。为此，我们对从世界各地的卡波西肉瘤患者收集的200个不同的KSHV样本的基因组进行了广泛的PCR DNA序列分析。在这里，我们回顾并总结了目前对KSHV变异性起源、KSHV及其人类宿主从非洲传播、嵌合基因组的存在以及基因组不同片段具有不同进化历史这一概念的理解。
