Rossi P, Albanesi C, Grimaldi P, Geremia R
Department of Public Health and Cell Biology, II University of Rome Tor Vergata, Italy.
Biochem Biophys Res Commun. 1991 Apr 30;176(2):910-4. doi: 10.1016/s0006-291x(05)80272-4.
The expression of the mRNA for SLF (the c-kit ligand), a product of the "steel" locus, has been investigated in postnatal mouse testis and homogeneous populations of testicular cells. The message was found expressed in postnatal mouse testis but not in germ cells. Studies on primary mouse Sertoli cell cultures from 18 day old mice show that Sertoli cells are the site of SLF mRNA expression in the seminiferous tubules. Treatment of Sertoli cell cultures with cAMP analogs led to a significant increase in the SLF mRNA levels.
对“Steel”位点产物SLF（c-kit配体）的mRNA在出生后小鼠睾丸及睾丸细胞均一群体中的表达情况进行了研究。发现该信使RNA在出生后小鼠睾丸中表达，但在生殖细胞中不表达。对来自18日龄小鼠的原代支持细胞培养物的研究表明，支持细胞是生精小管中SLF mRNA的表达位点。用cAMP类似物处理支持细胞培养物导致SLF mRNA水平显著增加。
