性器官发育研究。雏鸡苗勒氏管中细胞质雌激素受体的个体发生。
Studies on sex-organ development. Ontogeny of cytoplasmic oestrogen receptor in chick Müllerian duct.
作者信息
Teng C S, Teng C T
出版信息
Biochem J. 1975 Aug;150(2):191-4. doi: 10.1042/bj1500191.
Abstract
Oestradiol receptors were observed in the cytoplasm of the chick Müllerian duct at several embryonic stages. The sedimentation coefficients and the dissociation constants of the receptor protein remained unchanged throughout the various stages of development. Specific binding of cytoplasmic receptor to [3H]oestradiol assayed in vitro was shown to be saturable at concentration of 10nM or higher. The number of oeastradiol-binding sites on a per-cell basis increased linearly from day 8 to day 12 of incubation and then levelled off from day 12 to the fourth day after hatching. These results indicate that in the developing embryonic sex organ, the same receptor protein is present throughout prenatal development. The concentration of the oestradiol receptor increases and reaches a constant value, but the capacity for the receptor to interact with the hormone does not change.
摘要
在鸡苗勒氏管的细胞质中，在几个胚胎阶段都观察到了雌二醇受体。受体蛋白的沉降系数和解离常数在整个发育的各个阶段都保持不变。体外测定的细胞质受体与[3H]雌二醇的特异性结合在10nM或更高浓度下显示为可饱和。每细胞的雌二醇结合位点数量在孵化第8天到第12天呈线性增加，然后从第12天到孵化后第4天趋于稳定。这些结果表明，在发育中的胚胎性器官中，整个产前发育过程中都存在相同的受体蛋白。雌二醇受体的浓度增加并达到恒定值，但受体与激素相互作用的能力没有变化。
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