Shimoda K, Okamura S, Omori F, Mizuno Y, Hara T, Aoki T, Ueda K, Niho Y
First Department of Internal Medicine, Kyushu University, Fukuoka, Japan.
Blood. 1991 May 15;77(10):2214-7.
Granulocyte colony-stimulating factor (G-CSF) in the cerebrospinal fluid from patients with meningitis was measured by our modified enzyme-linked immunosorbent assay for G-CSF. The minimal detection level was 20 pg/mL G-CSF. In patients with bacterial meningitis, the G-CSF levels in the cerebrospinal fluid were extremely elevated, showing a mean value of approximately 1,500 pg/mL. On the other hand, G-CSF levels in the cerebrospinal fluid from 67% patients with aseptic meningitis were moderately increased, showing a mean value of about 80 pg/mL, whereas G-CSF levels in 33% samples remained undetectable. The G-CSF levels and neutrophil counts in the cerebrospinal fluid were proven to be related by Spearman's rank correlation coefficient analysis (r = .724). These elevations of G-CSF levels at inflammation sites associated with bacterial meningitis may indicate that G-CSF plays an important role in the combat of bacterial infections.
采用我们改良的粒细胞集落刺激因子（G-CSF）酶联免疫吸附测定法，对脑膜炎患者脑脊液中的G-CSF进行检测。最低检测水平为20 pg/mL G-CSF。在细菌性脑膜炎患者中，脑脊液中的G-CSF水平极度升高，平均值约为1500 pg/mL。另一方面，67%的无菌性脑膜炎患者脑脊液中的G-CSF水平中度升高，平均值约为80 pg/mL，而33%的样本中G-CSF水平仍检测不到。经Spearman等级相关系数分析证实，脑脊液中的G-CSF水平与中性粒细胞计数相关（r = 0.724）。与细菌性脑膜炎相关的炎症部位G-CSF水平的这些升高可能表明，G-CSF在对抗细菌感染中发挥着重要作用。
