Lindberg Peter, Andersson Britt, Bergh Anders, Ljungberg Börje, Lindahl Olof
Department of Applied Physics and Electronics, Umeå University, Umeå, Sweden.
Med Biol Eng Comput. 2006 Dec;44(12):1053-9. doi: 10.1007/s11517-006-0129-y. Epub 2006 Nov 9.
The purpose of this study was to improve a resonance sensor system for prostate cancer detection and evaluate its performance on silicone with different hardness. Furthermore, to investigate if the instrument could distinguish between cancerous and normal prostate tissue in one in vitro prostate specimen. The system could measure the frequency shift, impression depth and the rise time of the force signal. The frequency shift, impression depth and the rise time described the relative hardness of silicone (n = 50, P < 0.05). The results from measurements on the prostate specimen indicated that there is a significant difference in the parameter data between cancerous and normal prostate tissue (n = 15, P < 0.05). The parameters' impression depth and force rise time adds important information for cancer detection. Further studies on prostate tissue with different tumour types must be performed in order to understand the full value of the new sensor system.
本研究的目的是改进一种用于前列腺癌检测的共振传感器系统，并评估其在不同硬度硅胶上的性能。此外，研究该仪器能否在一个体外前列腺标本中区分癌性和正常前列腺组织。该系统可以测量频率偏移、压痕深度和力信号的上升时间。频率偏移、压痕深度和上升时间描述了硅胶的相对硬度（n = 50，P < 0.05）。对前列腺标本的测量结果表明，癌性和正常前列腺组织之间的参数数据存在显著差异（n = 15，P < 0.05）。参数压痕深度和力上升时间为癌症检测增添了重要信息。必须对不同肿瘤类型的前列腺组织进行进一步研究，以了解新传感器系统的全部价值。
