Morgan Craig, Kirkbride James, Leff Julian, Craig Tom, Hutchinson Gerard, McKenzie Kwame, Morgan Kevin, Dazzan Paola, Doody Gillian A, Jones Peter, Murray Robin, Fearon Paul
Division of Psychological Medicine, Institute of Psychiatry, London, UK.
Psychol Med. 2007 Apr;37(4):495-503. doi: 10.1017/S0033291706009330.
Numerous studies have reported high rates of psychosis in the Black Caribbean and Black African populations in the UK. However, few studies have investigated the role of specific risk factors in different ethnic groups. We sought to investigate the relationship between long-term separation from, and death of, a parent before the age of 16 and risk of adult psychosis in different ethnic groups.
All patients with a first episode of psychosis who made contact with psychiatric services in defined catchment areas in London and Nottingham, UK and a series of community controls were included in the AESOP (Aetiology and Ethnicity in Schizophrenia and Other Psychoses) study. Data relating to clinical and social variables, including parental separation and loss, were collected from patients and controls.
Separation from, and death of, a parent before the age of 16 were both strongly associated with a two- to threefold increased risk of psychosis. The strength of these associations were similar for White British and Black Caribbean (but not Black African) subjects. Separation from (but not death of) a parent was more common among Black Caribbean controls than White British controls.
Early separation may have a greater impact in the Black Caribbean population, because it is more common, and may contribute to the excess of psychosis in this population.
众多研究报告称，在英国的加勒比黑人及非洲黑人人群中，精神病发病率很高。然而，鲜有研究调查不同种族群体中特定风险因素的作用。我们试图研究16岁之前与父母长期分离或父母死亡与不同种族群体成人患精神病风险之间的关系。
在英国伦敦和诺丁汉的特定集水区与精神科服务机构接触的所有首次发作精神病患者以及一系列社区对照者都纳入了AESOP（精神分裂症及其他精神病的病因与种族）研究。从患者和对照者那里收集了与临床和社会变量相关的数据，包括父母离异和丧亲情况。
16岁之前与父母分离及父母死亡均与患精神病风险增加两到三倍密切相关。对于英国白人及加勒比黑人（但不包括非洲黑人）受试者而言，这些关联的强度相似。在加勒比黑人对照者中，与父母分离（而非父母死亡）的情况比英国白人对照者更为常见。
早期分离在加勒比黑人人群中可能影响更大，因为这种情况更为常见，且可能是该人群中精神病高发的原因之一。
