Wright K E, Buchmeier M J
Department of Neuropharmacology, Research Institute of Scripps Clinic, La Jolla, California 92037.
J Virol. 1991 Jun;65(6):3001-6. doi: 10.1128/JVI.65.6.3001-3006.1991.
The role of antiviral antibody in resistance to acute lymphocytic choriomeningitis virus infection has been examined by passive transfer of monoclonal antibodies and intracerebral challenge infection. Protection of mice from lethal T-cell-mediated acute disease was observed following passive administration of antibodies either 1 day before or up to 2 days after infection. Viral replication was suppressed in protected mice, and the cytotoxic T-cell response to virus was also diminished. Virus was cleared from the brain and other tissues of protected mice without development of lethal immunopathology, suggesting that preexisting antibody may play a significant role in modulating potentially destructive effects of T-cell-mediated immune responses to pathogens.
通过单克隆抗体的被动转移和脑内攻击感染，对抗病毒抗体在抵抗急性淋巴细胞性脉络丛脑膜炎病毒感染中的作用进行了研究。在感染前1天或感染后长达2天被动给予抗体后，观察到小鼠对致死性T细胞介导的急性疾病具有保护作用。在受保护的小鼠中病毒复制受到抑制，并且对病毒的细胞毒性T细胞反应也减弱。病毒从受保护小鼠的脑和其他组织中清除，未出现致死性免疫病理学，这表明预先存在的抗体可能在调节T细胞介导的对病原体免疫反应的潜在破坏作用中发挥重要作用。
