Keilp John G, Klain H Marie, Brodsky Beth, Oquendo Maria A, Gorlyn Marianne, Stanley Barbara, Mann J John
Department of Neuroscience, Columbia University Medical College and New York State Psychiatric Institute, Box 42, 1051 Riverside Drive, New York, NY 10032, USA.
Psychiatry Res. 2007 Jan 15;149(1-3):139-45. doi: 10.1016/j.psychres.2006.09.014. Epub 2006 Nov 9.
Backward masking is a measure of early visual information processing usually abnormal in psychotic disorders. Previous studies of subjects with Borderline Personality Disorder have been inconsistent regarding their impairment or lack of impairment on backward masking. We examined visual backward masking performance in samples of unmedicated depressed patients with (n=12) and without (n=16) Borderline Personality Disorder, and healthy volunteers (n=18). Accuracy was poorer in depressed BPD patients, relative to both non-BPD depressed and healthy comparison subjects. As in previous studies, no differences in accuracy were found between non-BPD depressed patients and healthy comparison subjects. Differences in BPD subjects' accuracy were most evident at the fastest ISI and were not attributable to intercurrent psychotic symptoms. Beyond these group differences, accuracy at faster ISI's correlated with self-ratings of impulsiveness in all patients, and may be a general correlate of this trait. Poor early information processing appears to be a feature of Borderline Personality Disorder, and may play a role in the impulsive behavior that is characteristic of the disorder.
逆向掩蔽是一种早期视觉信息处理的测量方法，在精神障碍中通常是异常的。先前对边缘型人格障碍患者的研究在他们在逆向掩蔽方面是否受损或未受损上并不一致。我们检查了未用药的伴有（n = 12）和不伴有（n = 16）边缘型人格障碍的抑郁症患者样本以及健康志愿者（n = 18）的视觉逆向掩蔽表现。相对于非边缘型人格障碍的抑郁症患者和健康对照受试者，边缘型人格障碍的抑郁症患者的准确性较差。与先前的研究一样，在非边缘型人格障碍的抑郁症患者和健康对照受试者之间未发现准确性差异。边缘型人格障碍受试者的准确性差异在最快的刺激间隔时间（ISI）时最为明显，并且不归因于并发的精神病性症状。除了这些组间差异外，更快刺激间隔时间时的准确性与所有患者的冲动性自评相关，并且可能是该特质的一个普遍相关因素。早期信息处理能力差似乎是边缘型人格障碍的一个特征，并且可能在该障碍所特有的冲动行为中起作用。
