Gou Zhongru, Weng Wenjian, Yan Weiqi, Du Piyi, Han Gaorong, Wang Zheng
State key Lab of Silicon Materials, Department of Materials Science and Engineering, Zhejiang University, Hangzhou, 310027, China.
J Control Release. 2006 Dec 1;116(3):360-4. doi: 10.1016/j.jconrel.2006.09.003. Epub 2006 Sep 19.
The multiple biologically active trace element delivery remains a problem in regeneration medicine and tissue engineering. A novel approach to fabricate the biologically active trace elements assembly in a core-shell system for cooperative controlled-release has been proposed. Firstly, using a pH-dependent electrostatic interaction, zinc and strontium ions were incorporated into the silica gel nanospheres. Subsequently a porous octacalcium phosphate (OCP) shell was coated on the nanospheres tailored by poly(acrylate sodium) molecules. In vitro test shows that this hierarchical multilayered nanostructure can achieve a shell-/pH-dependent controlled-release of silicon, strontium and zinc ions. The wet-chemical route to selective synthesis of the core-shell Silica@OCP system may provide a general model to develop cooperative encapsulation of biologically active ions in a silica-based system by using layer-by-layer assembly technique for controlled-release in biomedical areas.
在再生医学和组织工程中，多种生物活性微量元素的递送仍然是一个问题。已经提出了一种在核壳系统中制备生物活性微量元素组装体以实现协同控释的新方法。首先，利用pH依赖性静电相互作用，将锌离子和锶离子掺入硅胶纳米球中。随后，在由聚丙烯酸钠分子定制的纳米球上涂覆多孔八钙磷酸（OCP）壳。体外测试表明，这种分级多层纳米结构可以实现硅、锶和锌离子的壳层/ pH依赖性控释。通过湿化学途径选择性合成核壳二氧化硅@OCP系统，可能为利用逐层组装技术在基于二氧化硅的系统中协同封装生物活性离子以用于生物医学领域的控释提供一个通用模型。
