Key Lab for Nanomaterials of the Ministry of Education, Beijing University of Chemical Technology, Bei San Huan Dong Road 15, Beijing 100029, People's Republic of China.
Acta Biomater. 2010 Aug;6(8):3092-100. doi: 10.1016/j.actbio.2010.02.042. Epub 2010 Mar 1.
Two kinds of inorganic/organic hybrid composites based on mesoporous silica nanotubes (MSNTs) and pH-responsive polyelectrolytes have been developed as pH-controlled drug delivery systems via the layer by layer self-assembly technique. One system was based on alternatively loading poly(allylamine hydrochloride) and sodium poly(styrene sulfonate) onto as-prepared MSNTs to load and release the positively charged drug doxorubicin. The other system was synthesized by alternately coating sodium alginate and chitosan onto amine-functionalized MSNTs, which were used as vehicles for the loading and release of the negatively charged model drug sodium fluorescein. Controlled release of the drug molecules from these delivery systems was achieved by changing the pH value of the release medium. The results of in vitro cell cytotoxicity assays indicated that the cell killing efficacy of the loaded doxorubicin against human fibrosarcoma (HT-1080) and human breast adenocarcinoma (MCF-7) cells was pH dependent. Thus, these hybrid composites could be potentially applicable as pH-controlled drug delivery systems.
两种基于介孔硅纳米管（MSNTs）和 pH 响应性聚电解质的无机/有机杂化复合材料已被开发为 pH 控制药物输送系统，通过层层自组装技术。一个系统是基于将聚（盐酸烯丙胺）和聚（苯乙烯磺酸钠）交替负载到制备好的 MSNTs 上来负载和释放带正电荷的药物阿霉素。另一个系统是通过将海藻酸钠和壳聚糖交替涂覆到胺功能化的 MSNTs 上来合成的，它们被用作负载和释放带负电荷的模型药物荧光素钠的载体。通过改变释放介质的 pH 值，可以实现药物分子从这些输送系统中的控制释放。体外细胞细胞毒性试验的结果表明，负载阿霉素对人纤维肉瘤（HT-1080）和人乳腺癌（MCF-7）细胞的细胞杀伤效力是 pH 值依赖性的。因此，这些杂化复合材料可能适用于 pH 控制药物输送系统。
