Amresh G, Reddy G D, Rao Ch V, Singh P N
Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, Council of Scientific and Industrial Research, Rana Pratap Marg, Lucknow 226001, Uttar Pradesh, India.
J Ethnopharmacol. 2007 Apr 4;110(3):526-31. doi: 10.1016/j.jep.2006.10.009. Epub 2006 Oct 19.
In the present study, 50% ethanolic extract of Cissampelos pareira roots (CPE) in acute, subacute and chronic models of inflammation was assessed in rats. Per os (p.o.) administration of CPE (200, 400 mg/kg) exhibited significant anti-inflammatory activity. In acute inflammation as produced by carrageenin 59.55% and 64.04%, by histamine 15.38% and 30.77%, by 5-hydroxytryptamine 17.78% and 31.11% and by prostaglandin E(2)-induced hind paw edema 19.23% and 30.77% protection was observed. While in subacute anti-inflammatory models using formaldehyde-induced hind paw edema (after 1.5 h) 38.36% and 47.95% and in chronic anti-inflammatory model using cotton pellet granuloma 15.02% and 19.19% protection from inflammation was observed. CPE did not show any sign of toxicity and mortality up to a dose level of 1000 mg/kg, p.o. in rats. Both acute as well as chronic administration of CPE (100, 200 and 400 mg/kg, p.o.) did not produce any gastric lesion in rats. These data indicate that CPE possesses significant anti-inflammatory activity without ulcerogenic activity suggesting its potential as an anti-inflammatory agent for use in the treatment of various inflammatory diseases.
在本研究中，对大鼠急性、亚急性和慢性炎症模型评估了锡生藤根的50%乙醇提取物（CPE）。经口（p.o.）给予CPE（200、400mg/kg）表现出显著的抗炎活性。在角叉菜胶所致急性炎症中，观察到对后爪水肿的保护率分别为59.55%和64.04%；在组胺所致急性炎症中，保护率分别为15.38%和30.77%；在5-羟色胺所致急性炎症中，保护率分别为17.78%和31.11%；在前列腺素E(2)诱导的后爪水肿中，保护率分别为19.23%和30.77%。在亚急性抗炎模型中，使用甲醛诱导后爪水肿（1.5小时后），观察到的保护率分别为38.36%和47.95%；在慢性抗炎模型中，使用棉球肉芽肿，观察到的炎症保护率分别为15.02%和19.19%。在大鼠中，经口给予高达1000mg/kg剂量水平的CPE未显示任何毒性和死亡迹象。急性和慢性给予CPE（100、200和400mg/kg，p.o.）均未在大鼠中产生任何胃部病变。这些数据表明，CPE具有显著的抗炎活性且无致溃疡活性，提示其作为抗炎剂用于治疗各种炎症性疾病的潜力。
