蓝蓟全株提取物在实验动物中的抗炎和抗伤害感受活性。
Anti-inflammatory and anti-nociceptive activities of Fumaria indica whole plant extract in experimental animals.
作者信息
Rao Chandana Venkateswara, Verma Arti Raj, Gupta Praksh Kumar, Vijayakumar Madhavan
机构信息
Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, Rana Pratap Marg, Lucknow-226001, India.
出版信息
Acta Pharm. 2007 Dec;57(4):491-8. doi: 10.2478/v10007-007-0039-z.
The 50% ethanolic extract of Fumaria indica was investigated for its anti-inflammatory and antinociceptive potential in animal models. Oral administration of F. indica dry extract (100, 200 and 400 mg kg-1) exhibited dose dependent and significant anti-inflammatory activity in acute (carrageenean and histamine induced hind paw oedema, p < 0.05) and chronic cotton pellet granuloma models of inflammation, p < 0.01). The extract (400 mg kg-1) exhibited maximum anti-inflammatory effects of 42.2 and 42.1% after 3 h with carrageenean and histamine, respectively. The same dose of extract showed 38.9% reduction in granuloma mass in a chronic condition. A significant anti-nociceptive activity was evidenced in mice; 6.6-67.7% (p < 0.01) protection in mechanical, 33.9-125.1% (p < 0.05) protection in thermal induced pain and 22.2-73.9% (p < 0.05) protection in acetic acid-induced writhing.
研究了印度紫堇的50%乙醇提取物在动物模型中的抗炎和抗伤害感受潜力。口服印度紫堇干提取物（100、200和400 mg kg-1）在急性（角叉菜胶和组胺诱导的后爪水肿，p < 0.05）和慢性棉球肉芽肿炎症模型中表现出剂量依赖性且显著的抗炎活性（p < 0.01）。提取物（400 mg kg-1）在角叉菜胶和组胺作用3小时后分别表现出42.2%和42.1%的最大抗炎效果。相同剂量的提取物在慢性条件下使肉芽肿质量减少38.9%。在小鼠中证明了显著的抗伤害感受活性；在机械性疼痛中保护率为6.6 - 67.7%（p < 0.01），在热诱导疼痛中保护率为33.9 - 125.1%（p < 0.05），在醋酸诱导的扭体反应中保护率为22.2 - 73.9%（p < 0.05）。
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