Rao Chandana Venkateswara, Verma Arti Raj, Gupta Praksh Kumar, Vijayakumar Madhavan
Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, Rana Pratap Marg, Lucknow-226001, India.
Acta Pharm. 2007 Dec;57(4):491-8. doi: 10.2478/v10007-007-0039-z.
The 50% ethanolic extract of Fumaria indica was investigated for its anti-inflammatory and antinociceptive potential in animal models. Oral administration of F. indica dry extract (100, 200 and 400 mg kg-1) exhibited dose dependent and significant anti-inflammatory activity in acute (carrageenean and histamine induced hind paw oedema, p < 0.05) and chronic cotton pellet granuloma models of inflammation, p < 0.01). The extract (400 mg kg-1) exhibited maximum anti-inflammatory effects of 42.2 and 42.1% after 3 h with carrageenean and histamine, respectively. The same dose of extract showed 38.9% reduction in granuloma mass in a chronic condition. A significant anti-nociceptive activity was evidenced in mice; 6.6-67.7% (p < 0.01) protection in mechanical, 33.9-125.1% (p < 0.05) protection in thermal induced pain and 22.2-73.9% (p < 0.05) protection in acetic acid-induced writhing.
研究了印度紫堇的50%乙醇提取物在动物模型中的抗炎和抗伤害感受潜力。口服印度紫堇干提取物（100、200和400 mg kg-1）在急性（角叉菜胶和组胺诱导的后爪水肿，p < 0.05）和慢性棉球肉芽肿炎症模型中表现出剂量依赖性且显著的抗炎活性（p < 0.01）。提取物（400 mg kg-1）在角叉菜胶和组胺作用3小时后分别表现出42.2%和42.1%的最大抗炎效果。相同剂量的提取物在慢性条件下使肉芽肿质量减少38.9%。在小鼠中证明了显著的抗伤害感受活性；在机械性疼痛中保护率为6.6 - 67.7%（p < 0.01），在热诱导疼痛中保护率为33.9 - 125.1%（p < 0.05），在醋酸诱导的扭体反应中保护率为22.2 - 73.9%（p < 0.05）。
