Leentjens A F G, Driessen G, Weber W, Drukker M, van Os J
Department of Psychiatry, Maastricht University Hospital, Maastricht, The Netherlands.
Neuroepidemiology. 2008;30(2):71-5. doi: 10.1159/000116243. Epub 2008 Feb 14.
BACKGROUND/AIM: Parkinson's disease (PD) is often complicated by psychiatric comorbidity, which is likely to lead to a higher use of mental health care facilities. In addition, psychiatric symptomatology and associated mental health care use may be present even before motor symptoms and PD are diagnosed, as the pathophysiology of PD and its psychiatric consequences are likely to overlap to a degree. This will be reflected in an increasing mental health care use prior to the diagnosis of PD. The aim of this study is to compare the level of mental health care use of PD patients with that of a matched control population, and to assess possible fluctuations in mental health care use in the years surrounding the diagnosis of PD.
Record linkage study comparing the number of mental health care contacts by PD patients with that of a matched control population.
Mental health care use by PD patients already increased before the time of diagnosis of PD, and decreased again after diagnosis. The relative risk for mental health care use was increased from 3 years prior (RR 1.41; 95% CI 1.27-1.57) to 2 years after (RR 1.83; 95% CI 1.63-2.05) diagnosing PD. This increase was higher for women than for men, and higher for younger than older individuals.
The early pathophysiology of PD is expressed in part as mental health problems, suggesting the possibility of early detection in particular demographic groups and a proactive approach to early intervention for comorbid psychopathology.
背景/目的:帕金森病(PD)常伴有精神疾病共病,这可能导致对精神卫生保健设施的更高使用。此外,即使在运动症状出现及PD被诊断之前,精神症状及相关精神卫生保健使用情况可能就已存在,因为PD的病理生理学及其精神后果可能在一定程度上重叠。这将反映在PD诊断前精神卫生保健使用的增加。本研究的目的是比较PD患者与匹配对照人群的精神卫生保健使用水平,并评估PD诊断前后几年中精神卫生保健使用的可能波动情况。
通过记录链接研究比较PD患者与匹配对照人群的精神卫生保健接触次数。
PD患者的精神卫生保健使用在PD诊断前就已增加,诊断后又再次减少。精神卫生保健使用的相对风险从诊断PD前3年(RR 1.41;95%CI 1.27 - 1.57)增加到诊断后2年(RR 1.83;95%CI 1.63 - 2.05)。这种增加在女性中高于男性,在年轻人中高于老年人。
PD的早期病理生理学部分表现为精神健康问题,这表明在特定人群中早期检测以及对共病精神病理学进行积极早期干预的可能性。