不变残基对Rgg家族转录调节因子功能的贡献。
Contribution of invariant residues to the function of Rgg family transcription regulators.
作者信息
Loughman Jennifer A, Caparon Michael G
机构信息
Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110-1093, USA.
出版信息
J Bacteriol. 2007 Jan;189(2):650-5. doi: 10.1128/JB.01437-06. Epub 2006 Nov 10.
Abstract
The Rgg family of transcription regulators is widely distributed among gram-positive bacteria, yet how these proteins control transcription is poorly understood. Using Streptococcus pyogenes RopB as a model, we demonstrated that residues invariant among Rgg-like regulators are critical for function and obtained evidence for a mechanism involving protein complex formation.
摘要
转录调节因子的Rgg家族广泛分布于革兰氏阳性菌中，但人们对这些蛋白质如何控制转录了解甚少。以化脓性链球菌RopB为模型，我们证明了Rgg样调节因子中不变的残基对功能至关重要，并获得了涉及蛋白质复合物形成机制的证据。
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