Rehtanz Manuela, Ghim Shin-Je, Rector Annabel, Van Ranst Marc, Fair Patricia A, Bossart Gregory D, Jenson Alfred B
Harbor Branch Oceanographic Institution, Division of Marine Mammal Research and Conservation, 5600 US 1 North, Fort Pierce, FL 34946, USA.
James Graham Brown Cancer Center, Laboratory of Vaccinology, University of Louisville, 529 South Jackson Street, Louisville, KY 40202, USA.
J Gen Virol. 2006 Dec;87(Pt 12):3559-3565. doi: 10.1099/vir.0.82388-0.
A novel papillomavirus (PV) was isolated from a genital condyloma of a free-ranging bottlenose dolphin inhabiting the coastal waters of Charleston Harbor, SC, USA: Tursiops truncatus papillomavirus type 2 (TtPV2). This novel virus represents the first isolated North American cetacean PV and the first American bottlenose dolphin PV. After the viral genome was cloned, sequenced and characterized genetically, phylogenetic analyses revealed that TtPV2 is most similar to the only published cetacean PV isolated and characterized thus far, Phocoena spinipinnis PV type 1 (PsPV1). A striking feature of the genome of TtPV2, as well as that of PsPV1, is the lack of an E7 open reading frame, which typically encodes one of the oncogenic proteins believed to be responsible for malignant transformation in the high-risk mucosotropic human papillomaviruses (HPVs). TtPV2 E6 contains a PDZ-binding motif that has been shown to be involved in transformation in the case of high-risk genital HPVs.
从美国南卡罗来纳州查尔斯顿港沿海水域的一只自由放养的宽吻海豚的生殖器疣中分离出一种新型乳头瘤病毒（PV）：宽吻海豚乳头瘤病毒2型（TtPV2）。这种新型病毒是首个分离出的北美鲸类PV，也是首个美洲宽吻海豚PV。在病毒基因组被克隆、测序并进行遗传特征分析后，系统发育分析表明，TtPV2与迄今为止唯一已发表的经分离和特征分析的鲸类PV——棘鳍鼠海豚乳头瘤病毒1型（PsPV1）最为相似。TtPV2以及PsPV1的基因组的一个显著特征是缺乏E7开放阅读框，而在高危嗜黏膜型人乳头瘤病毒（HPV）中，E7开放阅读框通常编码一种被认为与恶性转化有关的致癌蛋白。TtPV2 E6含有一个PDZ结合基序，在高危生殖器HPV的情况下，该基序已被证明与转化有关。
