Santhana Krishnan S G, Pathalapati R, Kaplan L, Cobbs R K
Department of Nephrology, Long Island Jewish Medical Center, New Hyde Park, New York 11042, USA.
Postgrad Med J. 2006 Nov;82(973):e27. doi: 10.1136/pmj.2006.049809.
The case of a 39-year-old woman who was referred for weight gain and amenorrhoea is reported. Laboratory evaluation showed high levels of thyroid-stimulating hormone (TSH). The patient was started on increasing doses of levothyroxine for subclinical hypothyroidism. TSH remained persistently raised and the patient became thyrotoxic. Evaluation at another laboratory showed normal levels of TSH, raising the possibility of interfering substances. TSH levels were normalised with the addition of mouse serum to the patient's sample, confirming the presence of human anti-mouse antibodies as the interfering substance in the TSH assay.
报告了一名39岁因体重增加和闭经前来就诊的女性病例。实验室检查显示促甲状腺激素（TSH）水平升高。该患者因亚临床甲状腺功能减退开始服用递增剂量的左甲状腺素。TSH持续升高，患者出现甲状腺毒症。另一家实验室的检查显示TSH水平正常，提示可能存在干扰物质。在患者样本中加入小鼠血清后TSH水平恢复正常，证实人抗小鼠抗体是TSH检测中的干扰物质。
