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嗜异性血清抗体:血清促甲状腺激素水平假性升高的一个原因。

Heterophilic serum antibodies: a cause for falsely elevated serum thyrotropin levels.

作者信息

Brennan M D, Klee G G, Preissner C M, Hay I D

机构信息

Division of Endocrinology/Metabolism, Mayo Clinic, Rochester, MN 55905.

出版信息

Mayo Clin Proc. 1987 Oct;62(10):894-8. doi: 10.1016/s0025-6196(12)65044-7.

DOI:10.1016/s0025-6196(12)65044-7
PMID:3657306
Abstract

We report two cases of euthyroid patients with inappropriately elevated serum levels of thyrotropin (TSH) in whom investigation led to the detection of heterophilic antibodies. In addition, we compare the performance of two TSH immunometric assay systems in this setting. Even when monoclonal assay systems are used, TSH results must be critically interpreted when they are at variance with clinical and other biochemical findings.

摘要

我们报告了两例甲状腺功能正常但血清促甲状腺激素(TSH)水平异常升高的患者,对其进行检查后发现了嗜异性抗体。此外,我们比较了在此情况下两种TSH免疫测定系统的性能。即使使用单克隆测定系统,当TSH结果与临床及其他生化检查结果不一致时,也必须审慎解读。

相似文献

1
Heterophilic serum antibodies: a cause for falsely elevated serum thyrotropin levels.嗜异性血清抗体:血清促甲状腺激素水平假性升高的一个原因。
Mayo Clin Proc. 1987 Oct;62(10):894-8. doi: 10.1016/s0025-6196(12)65044-7.
2
Interference in thyrotropin (TSH) determination: falsely elevated TSH values in a transplanted patient.
Eur J Nucl Med. 1989;15(4):194-6. doi: 10.1007/BF00253793.
3
Artefactual increase in serum thyrotropin concentration caused by heterophilic antibodies with specificity for IgG of the family Bovidea.由对牛科动物IgG具有特异性的嗜异性抗体引起的血清促甲状腺激素浓度假性升高。
Clin Chem. 1986 Dec;32(12):2214-9.
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False hyperthyrotropinemia induced by heterophilic antibodies against rabbit serum.
J Clin Endocrinol Metab. 1981 Jul;53(1):200-2. doi: 10.1210/jcem-53-1-200.
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[Cases of Graves' disease with falsely high TSH values due to interfering substances which cross-link with mouse monoclonal antibodies in the TSH assay kits].
Nihon Naibunpi Gakkai Zasshi. 1993 Nov 20;69(10):1083-91. doi: 10.1507/endocrine1927.69.10_1083.
6
Heterophilic antibodies: a problem for all immunoassays.嗜异性抗体:所有免疫测定法面临的一个问题。
Clin Chem. 1988 Jan;34(1):27-33.
7
Interference by anti-immunoglobulin G antibodies in immunoradiometric assays of thyrotropin involving mouse monoclonal antibodies.抗免疫球蛋白G抗体在涉及小鼠单克隆抗体的促甲状腺激素免疫放射分析中的干扰作用。
Clin Chem. 1987 Jun;33(6):840-4.
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[Falsely elevated TSH value due to the presence of heterophilic antibodies].[由于存在嗜异性抗体导致促甲状腺激素(TSH)值假性升高]
Duodecim. 1983;99(18):1294-5.
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[A case with thyroid carcinoma associated with falsely increased TSH values].
Nihon Geka Gakkai Zasshi. 1997 Jan;98(1):68-70.
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Placental transfer of maternal anti-rabbit IgG causing falsely elevated TSH levels in neonates.母体抗兔IgG的胎盘转运导致新生儿促甲状腺激素(TSH)水平假性升高。
Acta Paediatr Scand. 1981 Sep;70(5):699-703. doi: 10.1111/j.1651-2227.1981.tb05771.x.

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