Sugaya Kimio, Nishijima Saori, Miyazato Minoru, Oda Masami, Ogawa Yoshihide
Division of Urology, Department of Organ-oriented Medicine, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan.
Biomed Res. 2006 Oct;27(5):211-7. doi: 10.2220/biomedres.27.211.
The influence of the nucleus reticularis pontis oralis (PoO) on the pontine micturition center (PMC) and pontine urine storage center (PUSC) was examined in decerebrate cats by electrical and chemical stimulations of the PMC, PUSC or PoO. Microinjection of carbachol into the rostral and dorsolateral part of the PoO rapidly inhibited reflex micturition and external urethral sphincter (EUS) activity. After confirming the inhibition of reflex micturition and EUS activity by microinjection of carbachol into the PoO, intravenous injection of atropine sulfate or its microinjection into the PoO recovered both reflex micturition and EUS activity. Microinjection of carbachol into the PMC evoked micturition and then inhibited reflex micturition, but intravenous injection of atropine or its microinjection into the PoO recovered reflex micturition. After confi rming the inhibition of reflex micturition and EUS activity by microinjection of carbachol into the PoO, electrical stimulation of the PUSC enhanced EUS activity, but electrical stimulation of the PMC failed to evoke micturition. However, electrical stimulation of the PMC evoked micturition after microinjection of atropine into the PoO. These results suggest that the PoO strongly inhibits the PMC and less strongly inhibits the PUSC. Therefore, the PoO seems to be the pontine micturition inhibitory area.
在去大脑猫中，通过对脑桥排尿中枢（PMC）、脑桥储尿中枢（PUSC）或脑桥嘴侧网状核（PoO）进行电刺激和化学刺激，研究了PoO对PMC和PUSC的影响。向PoO的嘴侧和背外侧部分微量注射卡巴胆碱可迅速抑制反射性排尿和尿道外括约肌（EUS）活动。在确认向PoO微量注射卡巴胆碱可抑制反射性排尿和EUS活动后，静脉注射硫酸阿托品或将其微量注射到PoO中可恢复反射性排尿和EUS活动。向PMC微量注射卡巴胆碱可诱发排尿，随后抑制反射性排尿，但静脉注射阿托品或将其微量注射到PoO中可恢复反射性排尿。在确认向PoO微量注射卡巴胆碱可抑制反射性排尿和EUS活动后，电刺激PUSC可增强EUS活动，但电刺激PMC未能诱发排尿。然而，在向PoO微量注射阿托品后，电刺激PMC可诱发排尿。这些结果表明，PoO强烈抑制PMC，较弱地抑制PUSC。因此，PoO似乎是脑桥排尿抑制区。
