Matsuzaki A
Department of Urology, Akita University School of Medicine.
Nihon Hinyokika Gakkai Zasshi. 1990 May;81(5):672-9. doi: 10.5980/jpnjurol1989.81.672.
In the present study it was attempted to investigate the urine storage function of the pons in the decerebrate cats. Firstly, the area where an increase in the urethral sphincter EMG activity was induced by electrical microstimulation in the ventrolateral part of the dorsolateral pontine tegmentum was identified. Next, the effect of electrical stimulation and chemical stimulations by carbachol, noradrenaline, enkephalin or GABA on the reflex micturition induced by bladder filling was studied. The sites of electrical and chemical stimulations were anatomically distributed in the nucleus locus subcoeruleus (LSC). The electrical stimulation of the LSC produced increases in the urethral sphincter EMG activity and in bladder capacity. The carbachol, noradrenaline and enkephalin microinjection into the LSC produced an increase in bladder capacity. On the other hand, the GABA injection produced decreases in bladder capacity and urethral sphincter EMG activity. From these results, it can be concluded that neurons in the LSC seem to perform an important role in the storage phase.
在本研究中，试图研究去大脑猫脑桥的储尿功能。首先，确定在背外侧脑桥被盖腹外侧部分通过微电刺激诱导尿道括约肌肌电图（EMG）活动增加的区域。接下来，研究电刺激以及卡巴胆碱、去甲肾上腺素、脑啡肽或γ-氨基丁酸（GABA）的化学刺激对膀胱充盈诱导的反射性排尿的影响。电刺激和化学刺激的部位在解剖学上分布于蓝斑下核（LSC）。对LSC进行电刺激会使尿道括约肌EMG活动和膀胱容量增加。向LSC内微量注射卡巴胆碱、去甲肾上腺素和脑啡肽会使膀胱容量增加。另一方面，注射GABA会使膀胱容量和尿道括约肌EMG活动降低。从这些结果可以得出结论，LSC中的神经元似乎在储尿期发挥重要作用。
