Sugaya K, Nishizawa O, Noto H, Tsukada T, Kohama T, Shimoda N, Harada T, Tsuchida S
Department of Urology, Akita University School of Medicine.
Hinyokika Kiyo. 1991 Dec;37(12):1639-44.
To identify the effective region of the pons in response to inaperisone which facilitates urine storage, inaperisone (100 mM, 0.2 microliters) was injected into the nucleus locus coeruleus alpha (LCa, the pontine micturition center), the nucleus locus subcoeruleus (LSC, the pontine urine storage center) and the nucleus reticularis pontis oralis (PoO, micturition inhibitory region) of the decerebrate cats. On reflex micturition, inaperisone injection into the LSC decreased voiding volume, and increased residual volume and bladder capacity, significantly. However, there was no difference in the maximum bladder pressure before and after inaperisone injection into the LSC. Inaperisone injection into the LCa or the PoO had no influence on reflex micturition. These results suggest that effective region of the pons in response to inaperisone is the LSC, and that inaperisone facilitates the urine storage neural mechanism in the LSC.
为了确定脑桥中对有助于储尿的异哌立松产生反应的有效区域，将异哌立松（100 mM，0.2微升）注射到去大脑猫的蓝斑α核（LCa，脑桥排尿中枢）、蓝斑下核（LSC，脑桥储尿中枢）和脑桥嘴侧网状核（PoO，排尿抑制区域）。在反射性排尿时，向LSC注射异哌立松可显著减少排尿量，增加残余尿量和膀胱容量。然而，向LSC注射异哌立松前后的最大膀胱压力没有差异。向LCa或PoO注射异哌立松对反射性排尿没有影响。这些结果表明，脑桥中对异哌立松产生反应的有效区域是LSC，并且异哌立松促进了LSC中的储尿神经机制。
