Mishkin G J
Vice President, Research and Development, Alcavis International, Inc., Gaithersburg, Md., USA.
Contrib Nephrol. 2007;154:72-83. doi: 10.1159/000096815.
More than 20% of the world's population use a catheter for dialysis, despite guidelines limiting their use. Although the structure and design of the catheters differ by manufacturer, the material used in central venous catheters and peritoneal dialysis catheters are the same across manufacturers. Given the long-term use of these catheters in the dialysis population, the good compatibility of the antiseptics and disinfectants used on the catheters is imperative to prevent failure and cracking of the catheter material. Tensile strengths of commercially available catheters were measured after exposure to commonly used disinfectants. The tensile strength was then compared between the catheters by analyzing the displacement vs. force (N) curves produced during the evaluation. A total of 44 catheter lumens were evaluated. The electrolytically produced sodium hypochlorite solution, Alcavis 50/ExSept Plus, was the only solution shown to be compatible with all three catheter materials resulting in a deviation of less than 10% for each of the different catheter types. Electrolytically produced sodium hypochlorite solutions were the only solutions in this study that did not alter the physical properties of any of the catheters after long-term exposure.
尽管有指南限制导管的使用，但全球仍有超过20%的人口使用导管进行透析。尽管不同制造商生产的导管结构和设计有所不同，但各制造商生产的中心静脉导管和腹膜透析导管所使用的材料是相同的。鉴于这些导管在透析人群中的长期使用，导管上使用的防腐剂和消毒剂具有良好的兼容性对于防止导管材料出现故障和破裂至关重要。在将市售导管暴露于常用消毒剂后，测量其拉伸强度。然后通过分析评估过程中产生的位移与力（N）曲线，对不同导管之间的拉伸强度进行比较。总共评估了44个导管内腔。电解生产的次氯酸钠溶液Alcavis 50/ExSept Plus是唯一被证明与所有三种导管材料都兼容的溶液，每种不同类型的导管的偏差均小于10%。电解生产的次氯酸钠溶液是本研究中唯一在长期暴露后不会改变任何导管物理性质的溶液。
