Berger Annette, Zareba Wojciech, Schneider Alexandra, Rückerl Regina, Ibald-Mulli Angela, Cyrys Josef, Wichmann H-Erich, Peters Annette
Institute of Epidemiology, GSF-National Research Center for Environment and Health, Ingolstaedter Landstrasse 1, D-85764 Neuherberg, Germany.
J Occup Environ Med. 2006 Nov;48(11):1149-58. doi: 10.1097/01.jom.0000245921.15916.03.
The authors conducted an investigation of the association between air pollution and arrhythmia.
A prospective panel study (October 2000-April 2001) was conducted in Erfurt, Germany. Fifty-seven men with coronary heart disease were subjected to six 24-hour electrocardiogram recordings. Runs of supraventricular and ventricular tachycardia were associated with continuous ultrafine particle counts (UFP), accumulation mode particle counts (ACP), PM2.5, and gaseous pollutants. Poisson and linear regression models were applied adjusting for trend, weekday, and meteorologic data.
Elevated concentrations of UFP, ACP, PM2.5, and nitrogen dioxide increased the risk for supraventricular runs and the number of ventricular runs at almost all lags. Statistically significant associations were found predominantly in the previous 24 to 71 hours and with the 5-day moving average.
Elevated concentrations of fine and ultrafine particle increased the risk of arrhythmia in men with coronary heart disease.
作者对空气污染与心律失常之间的关联进行了调查。
于2000年10月至2001年4月在德国埃尔福特进行了一项前瞻性队列研究。57名冠心病男性接受了6次24小时心电图记录。室上性和室性心动过速发作与连续超细颗粒物计数（UFP）、积聚模式颗粒物计数（ACP）、PM2.5和气态污染物相关。应用泊松和线性回归模型，并对趋势、工作日和气象数据进行了调整。
UFP、ACP、PM2.5和二氧化氮浓度升高几乎在所有滞后时间均增加了室上性发作风险和室性发作次数。具有统计学意义的关联主要在前24至71小时以及5天移动平均值中发现。
细颗粒物和超细颗粒物浓度升高增加了冠心病男性发生心律失常的风险。
