轮状病毒感染或接种疫苗后，针对VP4和VP7上血清型特异性及交叉反应性中和表位的抗体反应。
Antibody response to serotype-specific and cross-reactive neutralization epitopes on VP4 and VP7 after rotavirus infection or vaccination.
作者信息
Taniguchi K, Urasawa T, Kobayashi N, Ahmed M U, Adachi N, Chiba S, Urasawa S
机构信息
Department of Hygiene, Sapporo Medical College, Japan.
出版信息
J Clin Microbiol. 1991 Mar;29(3):483-7. doi: 10.1128/jcm.29.3.483-487.1991.
Abstract
By using a competitive solid-phase immunoassay with serotype-specific and cross-reactive neutralizing monoclonal antibodies directed at VP4 and VP7, we tested the antibody responses to some neutralization epitopes on VP4 and VP7 in individuals infected or vaccinated with rotavirus. Antibody responses to VP7 epitopes of the infecting serotype of virus were found at a high frequency in both infants and children. In contrast, antibody responses to VP4 and heterotypic VP7 were observed only when the individuals possessed antibodies to any serotype of rotavirus in their acute-phase or prevaccination sera.
摘要
通过使用一种竞争性固相免疫测定法，该方法采用针对VP4和VP7的血清型特异性及交叉反应性中和单克隆抗体，我们检测了轮状病毒感染或接种疫苗个体中针对VP4和VP7上一些中和表位的抗体反应。在婴儿和儿童中，对感染病毒血清型的VP7表位的抗体反应出现频率很高。相比之下，只有当个体在急性期或接种疫苗前血清中拥有针对任何轮状病毒血清型的抗体时，才会观察到对VP4和异型VP7的抗体反应。
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