Bryne M, Reibel J, Mandel U, Dabelsteen E
Department of Oral Pathology, University of Oslo, Norway.
J Oral Pathol Med. 1991 Mar;20(3):120-5. doi: 10.1111/j.1600-0714.1991.tb00904.x.
Recent studies have shown that changes within membrane bound carbohydrates may be essential for cellular differentiation and malignant transformation. We have therefore, by means of immunohistochemistry, studied the expression of T/Tn related (Thomsen-Friedenrich) carbohydrates in 13 oral lesions with squamous cell dysplasia. The epithelial grade of dysplasia was graded as mild, moderate or severe. The following carbohydrate structures were studied: Tn, T, mucintype 3 chain H, and the sialylated derivates, sialosyl-Tn and sialosyl-T. In general, short structures were detected on the basal cells and longer structures on the more mature spinous cells. In many cases, this sequential expression was more disturbed with increasing grade of epithelial dysplasia. However, our results also showed that some lesions with the same grade of epithelial dysplasia showed different carbohydrate expression. These findings indicate that expression of carbohydrates may supplement histologic diagnosis in the evaluation of the prognosis of premalignant lesions.
最近的研究表明，膜结合碳水化合物的变化可能对细胞分化和恶性转化至关重要。因此，我们通过免疫组织化学方法，研究了13例伴有鳞状细胞发育异常的口腔病变中T/Tn相关（汤姆森-弗里德赖希）碳水化合物的表达情况。发育异常的上皮分级为轻度、中度或重度。研究了以下碳水化合物结构：Tn、T、粘蛋白3型链H以及唾液酸化衍生物唾液酸基-Tn和唾液酸基-T。一般来说，在基底细胞上检测到短结构，在更成熟的棘细胞上检测到长结构。在许多情况下，随着上皮发育异常程度的增加，这种顺序表达受到的干扰更大。然而，我们的结果还表明，一些上皮发育异常程度相同的病变显示出不同的碳水化合物表达。这些发现表明，碳水化合物的表达可能在评估癌前病变的预后方面补充组织学诊断。
