细胞因子诱导艾滋病患者嗜碱性粒细胞释放组胺。细胞因子与特异性IgE抗体之间的相互作用。

Cytokine-induced histamine release from basophils of AIDS patients. Interaction between cytokines and specific IgE antibodies.

作者信息

Pedersen M, Permin H, Bindslev-Jensen C, Bendtzen K, Norn S

机构信息

Laboratory of Immunology, University Clinic for Infectious Diseases M, Copenhagen, Denmark.

出版信息

Allergy. 1991 Feb;46(2):129-34. doi: 10.1111/j.1398-9995.1991.tb00556.x.

DOI:10.1111/j.1398-9995.1991.tb00556.x

PMID:1710093

Abstract

Basophil leukocytes obtained from AIDS patients, allergic patients and healthy controls were stimulated in vitro with interleukin 4, lymphotoxin, tumour necrosis factor alpha and interferon gamma to examine the histamine releasing effect. The cytokines caused histamine release from the basophils of approximately half the AIDS patients and from 8-17% of the allergic patients. No response was obtained in the control group. Removal of cell surface immunoglobulins abolished the response to cytokines, indicating an Ig-dependent mechanism. Passive sensitization with cell-derived Ig, with Ig deprived of IgE, or with IgG, indicated that cell-bound IgE was responsible for the cytokine-induced histamine release in AIDS patients. This response may be mediated by cytokine-selective IgE antibodies.

摘要

从艾滋病患者、过敏患者和健康对照者中获取嗜碱性白细胞，在体外使用白细胞介素4、淋巴毒素、肿瘤坏死因子α和干扰素γ进行刺激，以检测组胺释放效应。这些细胞因子导致约一半艾滋病患者的嗜碱性粒细胞释放组胺，以及8%-17%的过敏患者的嗜碱性粒细胞释放组胺。对照组未出现反应。去除细胞表面免疫球蛋白可消除对细胞因子的反应，表明存在一种Ig依赖性机制。用细胞源性Ig、去除IgE的Ig或IgG进行被动致敏，表明细胞结合的IgE是艾滋病患者细胞因子诱导组胺释放的原因。这种反应可能由细胞因子选择性IgE抗体介导。