Pedersen M, Permin H, Bendtzen K, Norn S
Laboratory of Immunology, University Clinic for Infectious Diseases M, Rigshospitalet, Copenhagen, Denmark.
Agents Actions. 1990 Apr;30(1-2):294-6. doi: 10.1007/BF01969065.
Cytokine-induced histamine release from basophil leukocytes was examined in cell suspension from AIDS patients and compared with healthy controls. Cells from approximately half of the AIDS patients, in contrast to none from the control group, showed histamine release after stimulation with interleukin-4 (IL-4), tumor necrosis factor alpha (TNF alpha), lymphotoxin (LT) and interferon gamma (IFN gamma). These cytokines seem to induce histamine release from cells from AIDS patients by interaction with the cell surface immunoglobulins, since removal of the immunoglobulins prior to the exposure of the cytokines completely abolished the response to the cytokines. IL-1 alpha, IL-1 beta, IL-3, colony stimulating factor (CSF) and granulocyte-macrophage-CSF (GM-CSF) caused significant histamine release from cells from a similar number of AIDS patients and controls.
在艾滋病患者的细胞悬液中检测了细胞因子诱导嗜碱性白细胞释放组胺的情况，并与健康对照进行了比较。与对照组无一例出现组胺释放不同，大约一半艾滋病患者的细胞在用白细胞介素-4（IL-4）、肿瘤坏死因子α（TNFα）、淋巴毒素（LT）和干扰素γ（IFNγ）刺激后出现组胺释放。这些细胞因子似乎通过与细胞表面免疫球蛋白相互作用，诱导艾滋病患者细胞释放组胺，因为在细胞因子暴露前去除免疫球蛋白可完全消除对细胞因子的反应。白细胞介素-1α、白细胞介素-1β、白细胞介素-3、集落刺激因子（CSF）和粒细胞-巨噬细胞集落刺激因子（GM-CSF）在数量相似的艾滋病患者和对照组细胞中均引起了显著的组胺释放。
