Pedersen M, Permin H, Norn S, Skov P S
University Clinic for Infectious Diseases M, Rigshospitalet, Copenhagen, Denmark.
Allergy. 1989 Sep;44(7):460-6. doi: 10.1111/j.1398-9995.1989.tb04183.x.
AIDS patients in contrast to healthy individuals show basophil histamine release by stimulation in vitro of their blood leukocytes with Candida albicans (CA) and Herpes simplex virus Type I (HSV-I). Passive sensitization of cells from healthy individuals with the patient serum or surface immunoglobulins (Ig) derived from leukocytes of AIDS patients caused histamine release by the following stimulation of the cells with CA or HSV-I. When IgE was removed from the surface Ig no response was obtained, whereas a removal of IgG did not diminish the response. In contrast, no passive sensitization was obtained by serum derived from healthy individuals. The results show that IgE is responsible for the histamine release caused by CA and HSV-I in AIDS patients.
与健康个体相比，艾滋病患者的血液白细胞在体外经白色念珠菌（CA）和单纯疱疹病毒I型（HSV-I）刺激后，嗜碱性粒细胞会释放组胺。用患者血清或源自艾滋病患者白细胞的表面免疫球蛋白（Ig）对健康个体的细胞进行被动致敏，随后用CA或HSV-I刺激这些细胞会导致组胺释放。当从表面Ig中去除IgE时，未获得反应，而去除IgG并未减弱反应。相比之下，健康个体的血清未产生被动致敏作用。结果表明，IgE是导致艾滋病患者CA和HSV-I引起组胺释放的原因。
