Pedersen M, Nielsen C M, Permin H, Norn S
University Clinic for Infectious Diseases M, Rigshospitalet, Copenhagen, Denmark.
Agents Actions. 1989 Apr;27(1-2):55-7. doi: 10.1007/BF02222197.
HIV antigen-induced histamine release was examined in leukocyte suspensions from 12 patients with AIDS and 10 healthy controls. Nine of the twelve patients released histamine, while no release was obtained in cells from the control group. The mechanism was examined by removal of immunoglobulins (Ig) from the patient cells before stimulation with HIV antigen, which resulted in an abolition of the histamine release. Transfer of the Ig to cells from normal individuals rendered these cells able to respond to HIV. The removal and fixation of Ig were followed by disappearance and reappearance of the response to anti-IgE. These findings indicate that the histamine release by HIV is caused by a type I (IgE-mediated) reaction.
在12例艾滋病患者和10名健康对照者的白细胞悬液中检测了HIV抗原诱导的组胺释放。12例患者中有9例释放组胺，而对照组细胞未出现组胺释放。通过在HIV抗原刺激前去除患者细胞中的免疫球蛋白（Ig）来研究其机制，结果组胺释放被消除。将Ig转移至正常个体的细胞使其能够对HIV作出反应。去除并固定Ig后，对抗IgE的反应消失并重新出现。这些发现表明，HIV诱导的组胺释放是由I型（IgE介导）反应引起的。
