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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Lomonte B, Furtado M F, Rovira M E, Carmona E, Rojas G, Aymerich R, Gutiérrez J M

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José.

Braz J Med Biol Res. 1990;23(5):427-35.

The presence of proteins antigenically related to Bothrops asper myotoxins in various snake venoms, mainly from South America, was investigated by using polyclonal and monoclonal antibodies. 2. Myotoxin-like components were detected in ten Bothrops venoms from South America, and in the venoms of Crotalus atrox (North America), Trimeresurus flavoviridis (Japan), and Micrurus alleni (Costa Rica). 3. Cross-reactive components detected in several Bothrops venoms show a common subunit of 15-16 kDa by sodium dodecyl sulphate-polyacrylamide gel electrophoresis, although significant charge variations are evident by immunoelectrophoresis. 4. It is concluded that proteins antigenically related to B. asper myotoxins are relatively common in the genus Bothrops and, in the light of findings discussed, are likely to possess myotoxic activity.

利用多克隆抗体和单克隆抗体，对主要来自南美洲的各种蛇毒中与矛头蝮肌毒素存在抗原相关性的蛋白质进行了研究。2. 在十种来自南美洲的矛头蝮蛇毒以及北美西部菱斑响尾蛇、日本竹叶青蛇和哥斯达黎加艾伦珊瑚蛇的蛇毒中检测到了肌毒素样成分。3. 通过十二烷基硫酸钠 - 聚丙烯酰胺凝胶电泳，在几种矛头蝮蛇毒中检测到的交叉反应成分显示出一个15 - 16 kDa的共同亚基，尽管免疫电泳显示出明显的电荷差异。4. 得出的结论是，与矛头蝮肌毒素存在抗原相关性的蛋白质在矛头蝮属中相对常见，并且根据所讨论的研究结果，它们可能具有肌毒性活性。

Lomonte B, Furtado M F, Rovira M E, Carmona E, Rojas G, Aymerich R, Gutiérrez J M

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José.

Braz J Med Biol Res. 1990;23(5):427-35.

The presence of proteins antigenically related to Bothrops asper myotoxins in various snake venoms, mainly from South America, was investigated by using polyclonal and monoclonal antibodies. 2. Myotoxin-like components were detected in ten Bothrops venoms from South America, and in the venoms of Crotalus atrox (North America), Trimeresurus flavoviridis (Japan), and Micrurus alleni (Costa Rica). 3. Cross-reactive components detected in several Bothrops venoms show a common subunit of 15-16 kDa by sodium dodecyl sulphate-polyacrylamide gel electrophoresis, although significant charge variations are evident by immunoelectrophoresis. 4. It is concluded that proteins antigenically related to B. asper myotoxins are relatively common in the genus Bothrops and, in the light of findings discussed, are likely to possess myotoxic activity.

利用多克隆抗体和单克隆抗体，对主要来自南美洲的各种蛇毒中与矛头蝮肌毒素存在抗原相关性的蛋白质进行了研究。2. 在十种来自南美洲的矛头蝮蛇毒以及北美西部菱斑响尾蛇、日本竹叶青蛇和哥斯达黎加艾伦珊瑚蛇的蛇毒中检测到了肌毒素样成分。3. 通过十二烷基硫酸钠 - 聚丙烯酰胺凝胶电泳，在几种矛头蝮蛇毒中检测到的交叉反应成分显示出一个15 - 16 kDa的共同亚基，尽管免疫电泳显示出明显的电荷差异。4. 得出的结论是，与矛头蝮肌毒素存在抗原相关性的蛋白质在矛头蝮属中相对常见，并且根据所讨论的研究结果，它们可能具有肌毒性活性。