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Further questions regarding the role of mosaic penA sequences in conferring reduced susceptibility to ceftriaxone in Neisseria gonorrhoeae.关于嵌合penA序列在淋病奈瑟菌对头孢曲松敏感性降低中所起作用的进一步问题。
Antimicrob Agents Chemother. 2007 Feb;51(2):802-3. doi: 10.1128/AAC.01307-06. Epub 2006 Nov 13.
2
Real-time PCR and subsequent pyrosequencing for screening of penA mosaic alleles and prediction of reduced susceptibility to expanded-spectrum cephalosporins in Neisseria gonorrhoeae.实时聚合酶链反应及后续焦磷酸测序用于淋病奈瑟菌中penA镶嵌等位基因的筛查及对超广谱头孢菌素敏感性降低的预测
APMIS. 2008 Nov;116(11):1004-8. doi: 10.1111/j.1600-0463.2008.01062.x.
3
Analysis of mutations within multiple genes associated with resistance in a clinical isolate of Neisseria gonorrhoeae with reduced ceftriaxone susceptibility that shows a multidrug-resistant phenotype.对一株头孢曲松敏感性降低且表现出多重耐药表型的淋病奈瑟菌临床分离株中与耐药相关的多个基因内的突变进行分析。
Int J Antimicrob Agents. 2006 Jan;27(1):20-6. doi: 10.1016/j.ijantimicag.2005.08.021. Epub 2005 Nov 28.
4
A real-time PCR assay for detecting a penA mutation associated with ceftriaxone resistance in Neisseria gonorrhoeae.一种用于检测淋病奈瑟菌中与头孢曲松耐药相关的 penA 突变的实时 PCR 检测方法。
J Glob Antimicrob Resist. 2019 Dec;19:46-49. doi: 10.1016/j.jgar.2019.02.011. Epub 2019 Feb 27.
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Ceftriaxone-Resistant Neisseria gonorrhoeae, Canada, 2017.2017 年加拿大耐头孢曲松淋病奈瑟菌。
Emerg Infect Dis. 2018 Feb;24(2):381-3. doi: 10.3201/eid2402.171756. Epub 2018 Feb 17.
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Unique combined penA/mtrR/porB mutations and NG-MAST strain types associated with ceftriaxone and cefixime MIC increases in a 'susceptible' Neisseria gonorrhoeae population.独特的联合 penA/mtrR/porB 突变和 NG-MAST 菌株类型与“敏感”淋病奈瑟菌人群中头孢曲松和头孢克肟 MIC 增加相关。
J Antimicrob Chemother. 2014 Jun;69(6):1510-6. doi: 10.1093/jac/dkt543. Epub 2014 Feb 13.
7
Emergence and characterization of Neisseria gonorrhoeae isolates with decreased susceptibilities to ceftriaxone and cefixime in Canada: 2001-2010.加拿大对头孢曲松和头孢克肟敏感性降低的淋病奈瑟菌分离株的出现和特征：2001-2010 年。
Sex Transm Dis. 2012 Apr;39(4):316-23. doi: 10.1097/OLQ.0b013e3182401b69.
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Alterations of the pilQ gene in Neisseria gonorrhoeae are unlikely contributors to decreased susceptibility to ceftriaxone and cefixime in clinical gonococcal strains.淋病奈瑟菌 pilQ 基因突变不太可能导致临床淋病分离株对头孢曲松和头孢克肟的敏感性降低。
J Antimicrob Chemother. 2010 Dec;65(12):2543-7. doi: 10.1093/jac/dkq377. Epub 2010 Oct 12.
9
Analysis of mutations in multiple loci of Neisseria gonorrhoeae isolates reveals effects of PIB, PBP2 and MtrR on reduced susceptibility to ceftriaxone.分析淋病奈瑟菌分离株多个基因座的突变揭示了 PIB、PBP2 和 MtrR 对头孢曲松低敏性的影响。
J Antimicrob Chemother. 2011 May;66(5):1016-23. doi: 10.1093/jac/dkr021. Epub 2011 Feb 22.
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A Case of Decreased Susceptibility to Ceftriaxone in Neisseria gonorrhoeae in the Absence of a Mosaic Penicillin-Binding Protein 2 (penA) Allele.一例淋病奈瑟菌中头孢曲松敏感性降低且不存在镶嵌型青霉素结合蛋白2（penA）等位基因的病例
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1
Gonococcal resistance: are cephalosporins next?淋球菌耐药性：头孢菌素类药物会是下一个吗？
Curr Infect Dis Rep. 2011 Apr;13(2):196-204. doi: 10.1007/s11908-011-0169-9.
2
Various penA mutations together with mtrR, porB and ponA mutations in Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime or ceftriaxone.淋病奈瑟菌分离株中 penA 突变与 mtrR、porB 和 ponA 突变共同导致对头孢克肟或头孢曲松的低敏感性。
J Antimicrob Chemother. 2010 Apr;65(4):669-75. doi: 10.1093/jac/dkp505. Epub 2010 Jan 21.
3
Characteristics and population dynamics of mosaic penA allele-containing Neisseria gonorrhoeae isolates collected in Sydney, Australia, in 2007-2008.2007-2008 年在澳大利亚悉尼采集的含有 mosaic penA 等位基因的淋病奈瑟菌分离株的特征和种群动态。
Antimicrob Agents Chemother. 2010 Jan;54(1):554-6. doi: 10.1128/AAC.01108-09. Epub 2009 Nov 16.
4
The use of cephalosporins for gonorrhea: the impending problem of resistance.头孢菌素用于淋病治疗：迫在眉睫的耐药性问题。
Expert Opin Pharmacother. 2009 Mar;10(4):555-77. doi: 10.1517/14656560902731993.
5
Rapid detection of the mosaic structure of the Neisseria gonorrhoeae penA Gene, which is associated with decreased susceptibilities to oral cephalosporins.快速检测淋病奈瑟菌penA基因的镶嵌结构，该结构与口服头孢菌素敏感性降低有关。
J Clin Microbiol. 2008 May;46(5):1804-10. doi: 10.1128/JCM.01800-07. Epub 2008 Mar 26.
6
Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone.来自澳大利亚悉尼的淋病奈瑟菌菌株中，对头孢曲松敏感性降低的penA改变和亚型的多样性。
Antimicrob Agents Chemother. 2007 Sep;51(9):3111-6. doi: 10.1128/AAC.00306-07. Epub 2007 Jun 25.
7
Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA.对头孢克肟和头孢曲松敏感性降低的淋病奈瑟菌分离株：与penA、mtrR、porB1b和ponA基因多态性的关联
Antimicrob Agents Chemother. 2007 Jun;51(6):2117-22. doi: 10.1128/AAC.01604-06. Epub 2007 Apr 9.

本文引用的文献

1
Amino acid substitutions in mosaic penicillin-binding protein 2 associated with reduced susceptibility to cefixime in clinical isolates of Neisseria gonorrhoeae.在淋病奈瑟菌临床分离株中，镶嵌青霉素结合蛋白2中的氨基酸替换与对头孢克肟敏感性降低相关。
Antimicrob Agents Chemother. 2006 Nov;50(11):3638-45. doi: 10.1128/AAC.00626-06. Epub 2006 Aug 28.
2
Analysis of mutations within multiple genes associated with resistance in a clinical isolate of Neisseria gonorrhoeae with reduced ceftriaxone susceptibility that shows a multidrug-resistant phenotype.对一株头孢曲松敏感性降低且表现出多重耐药表型的淋病奈瑟菌临床分离株中与耐药相关的多个基因内的突变进行分析。
Int J Antimicrob Agents. 2006 Jan;27(1):20-6. doi: 10.1016/j.ijantimicag.2005.08.021. Epub 2005 Nov 28.
3
Emergence and spread of Neisseria gonorrhoeae clinical isolates harboring mosaic-like structure of penicillin-binding protein 2 in Central Japan.日本中部地区携带青霉素结合蛋白2镶嵌样结构的淋病奈瑟菌临床分离株的出现与传播
Antimicrob Agents Chemother. 2005 Jan;49(1):137-43. doi: 10.1128/AAC.49.1.137-143.2005.
4
Mosaic-like structure of penicillin-binding protein 2 Gene (penA) in clinical isolates of Neisseria gonorrhoeae with reduced susceptibility to cefixime.对头孢克肟敏感性降低的淋病奈瑟菌临床分离株中青霉素结合蛋白2基因（penA）的镶嵌样结构
Antimicrob Agents Chemother. 2002 Dec;46(12):3744-9. doi: 10.1128/AAC.46.12.3744-3749.2002.
5
Hybrid penicillin-binding proteins in penicillin-resistant strains of Neisseria gonorrhoeae.淋病奈瑟菌青霉素耐药菌株中的杂合青霉素结合蛋白。
Nature. 1988 Mar 10;332(6160):173-6. doi: 10.1038/332173a0.

Further questions regarding the role of mosaic penA sequences in conferring reduced susceptibility to ceftriaxone in Neisseria gonorrhoeae.

作者信息

Whiley David M, Limnios E Athena, Ray Sanghamitra, Sloots Theo P, Tapsall John W

出版信息

Antimicrob Agents Chemother. 2007 Feb;51(2):802-3. doi: 10.1128/AAC.01307-06. Epub 2006 Nov 13.

DOI:10.1128/AAC.01307-06
PMID:17101673
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1797742/
Abstract
摘要