Mazza S, Soucy J P, Gravel P, Michaud M, Postuma R, Massicotte-Marquez J, Decary A, Montplaisir J
Centre d'Etude du Sommeil et des Rythmes Biologiques, Hôpital du Sacré-Coeur de Montréal, 5400 Boul. Gouin Ouest, Montréal, Québec, Canada, H4J 1C5.
Neurology. 2006 Nov 14;67(9):1618-22. doi: 10.1212/01.wnl.0000242879.39415.49.
To investigate the regional cerebral perfusion in patients with idiopathic REM behavior disorder (RBD) in order to establish the topography of networks involved.
We performed cerebral blood flow evaluation using (99m)Tc-Ethylene Cysteinate Dimer (ECD) SPECT on eight patients with polysomnographically confirmed RBD and nine age-matched controls. Comparisons were made using SPM2.
We found increased perfusion in the pons and putamen bilaterally and in the right hippocampus. In addition, we observed a decreased perfusion in frontal (Brodmann area [BA] 4, 6, 10, 43, 44, 47 bilaterally and left BA 9, 46) and temporo-parietal (BA 13, 22, 43 bilaterally and left BA 7, 19, 20, 21, 39, 40, 41, 42) cortices.
Perfusional abnormalities in patients with REM behavior disorder were located in the brainstem, striatum, and cortex. These abnormalities are consistent with the anatomic metabolic profile of Parkinson disease.
研究特发性快速眼动睡眠行为障碍（RBD）患者的脑区灌注情况，以确定相关神经网络的地形图。
我们对8例经多导睡眠图证实为RBD的患者和9例年龄匹配的对照者进行了（99m）锝-乙半胱氨酸二聚体（ECD）单光子发射计算机断层扫描（SPECT）脑血流评估。使用SPM2进行比较。
我们发现双侧脑桥、壳核以及右侧海马灌注增加。此外，我们观察到额叶（双侧Brodmann区[BA]4、6、10、43、44、47以及左侧BA9、46）和颞顶叶（双侧BA13、22、43以及左侧BA7、19、20、21、39、40、41、42）皮质灌注减少。
快速眼动睡眠行为障碍患者的灌注异常位于脑干、纹状体和皮质。这些异常与帕金森病的解剖代谢特征一致。
