Okuno T, Shindo M, Arai K, Matsumoto M, Takeda M, Kashima K, Sokawa Y
Department of Internal Medicine, Akashi Municipal Hospital, Japan.
Gastroenterol Jpn. 1991 Apr;26(2):162-9. doi: 10.1007/BF02811075.
We measured the sequential changes in 2',5' oligoadenylate synthetase activity in 21 patients with acute viral hepatitis (5 with type A, 6 with type B, and 10 with type non-A, non-B hepatitis) by radioimmunoassay. Liver biopsies were performed during the acute phase in all patients. Among patients with acute hepatitis A and B, the 2',5' oligoadenylate synthetase levels were transiently elevated at the time of the peak alanine aminotransferase level in the patients in whom a liver biopsy showed acute hepatitis or non-specific reactive hepatitis. Of 10 patients with acute non-A, non-B hepatitis, 4 showed a similar 2',5' oligoadenylate synthetase activity pattern and liver histology to those observed in acute hepatitis A and B. In the remaining 6, the 2',5' oligoadenylate synthetase levels remained elevated for 3.5 to 6 months while the alanine aminotransferase was elevated. Liver biopsy in these patients showed chronic hepatitis. Persistent detection of raised 2',5' oligoadenylate synthetase activity levels during the acute stage of non-A, non-B hepatitis may thus be an indicator of progression of the disease.
我们通过放射免疫测定法测量了21例急性病毒性肝炎患者（5例甲型肝炎、6例乙型肝炎和10例非甲非乙型肝炎）中2',5'-寡腺苷酸合成酶活性的连续变化。所有患者均在急性期进行了肝活检。在急性甲型和乙型肝炎患者中，在肝活检显示为急性肝炎或非特异性反应性肝炎的患者中，当丙氨酸转氨酶水平达到峰值时，2',5'-寡腺苷酸合成酶水平短暂升高。10例急性非甲非乙型肝炎患者中，4例表现出与急性甲型和乙型肝炎患者相似的2',5'-寡腺苷酸合成酶活性模式和肝脏组织学特征。其余6例患者中，2',5'-寡腺苷酸合成酶水平在丙氨酸转氨酶升高期间持续升高3.5至6个月。这些患者的肝活检显示为慢性肝炎。因此，在非甲非乙型肝炎急性期持续检测到升高的2',5'-寡腺苷酸合成酶活性水平可能是疾病进展的一个指标。
