Li Zhi, Lee Daeyeon, Sheng Xiaoxia, Cohen Robert E, Rubner Michael F
Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Langmuir. 2006 Nov 21;22(24):9820-3. doi: 10.1021/la0622166.
Using a combination of an aqueous layer-by-layer deposition technique, nanoparticle surface modification chemistry, and nanoreactor chemistry, we constructed thin film coatings with two distinct layered functional regions: a reservoir for the loading and release of bactericidal chemicals and a nanoparticle surface cap with immobilized bactericides. This results in dual-functional bactericidal coatings bearing both chemical-releasing bacteria-killing capacity and contact bacteria-killing capacity. These dual-functional coatings showed very high initial bacteria-killing efficiency due to the release of Ag ions and retained significant antibacterial activity after the depletion of embedded Ag because of the immobilized quaternary ammonium salts.
通过结合水相逐层沉积技术、纳米颗粒表面改性化学和纳米反应器化学，我们构建了具有两个不同分层功能区域的薄膜涂层：一个用于装载和释放杀菌化学物质的储存库，以及一个带有固定化杀菌剂的纳米颗粒表面帽。这产生了兼具化学释放杀菌能力和接触杀菌能力的双功能杀菌涂层。由于银离子的释放，这些双功能涂层显示出非常高的初始杀菌效率，并且在嵌入的银耗尽后，由于固定化的季铵盐，仍保留显著的抗菌活性。
