WCU Program of Chemical Convergence for Energy and Environment (C2E2), School of Chemical and Biological Engineering, College of Engineering, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
Colloids Surf B Biointerfaces. 2011 Feb 1;82(2):651-6. doi: 10.1016/j.colsurfb.2010.10.027. Epub 2010 Oct 20.
Quaternary ammonium compounds have been considered as excellent antibacterial agents due to their effective biocidal activity, long term durability and environmentally friendly performance. In this work, 3-(trimethoxysilyl)-propyldimethyloctadecylammonium chloride as a quaternary ammonium silane was applied for the surface modification of silica nanoparticles. The quaternary ammonium silane provided silica surface with hydrophobicity and antibacterial properties. In addition, the glass surface which was coated with the surface modified silica nanoparticles presented bacterial growth inhibition activity. For comparison of bacterial growth resistance, hydrophobic silane (alkyl functionalized silane) modified silica nanoparticles and pristine silica nanoparticles were prepared. As a result of bacterial adhesion test, the quaternary ammonium functionalized silica nanoparticles exhibited the enhanced inhibition performance against growth of Gram-negative Escherichia coli (96.6%), Gram-positive Staphylococcus aureus (98.5%) and Deinococcus geothermalis (99.6%) compared to pristine silica nanoparticles. These bacteria resistances also were stronger than that of hydrophobically modified silica nanoparticles. It could be explained that the improved bacteria inhibition performance originated from the synergistic effect of hydrophobicity and antibacterial property of quaternary ammonium silane. Additionally, the antimicrobial efficacy of the fabricated nanoparticles increased with decreasing size of the nanoparticles.
季铵盐因其有效的杀菌活性、长期耐久性和环境友好性能而被认为是极好的抗菌剂。在这项工作中，3-（三甲氧基硅基）丙基二甲基十八烷基氯化铵作为季铵硅烷，用于二氧化硅纳米粒子的表面改性。季铵硅烷赋予二氧化硅表面疏水性和抗菌性能。此外，涂覆有经表面改性的二氧化硅纳米粒子的玻璃表面呈现出抑制细菌生长的活性。为了比较细菌生长的抗性，制备了疏水硅烷（烷基官能化硅烷）改性的二氧化硅纳米粒子和原始的二氧化硅纳米粒子。通过细菌粘附试验，与原始的二氧化硅纳米粒子相比，季铵功能化的二氧化硅纳米粒子对革兰氏阴性大肠杆菌（96.6%）、革兰氏阳性金黄色葡萄球菌（98.5%）和地热能球菌（99.6%）的生长表现出增强的抑制性能。这些细菌的抗性也强于疏水性改性的二氧化硅纳米粒子。这可以解释为，抗菌性能的提高源于季铵硅烷的疏水性和抗菌性能的协同效应。此外，所制备的纳米粒子的抗菌功效随着纳米粒子尺寸的减小而增加。
