Godleski John J
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA.
Clin Occup Environ Med. 2006;5(4):849-64. doi: 10.1016/j.coem.2006.07.002.
This article focuses on responses to ambient particles by the heart. Available data from human studies and animal studies are reviewed in an attempt to find a common understanding in the findings. The pathophysiologic mechanisms responsible for these health effects are likely to be complex, and it is highly probable that several different mechanisms work in concert. Current evidence suggests that inhaled particles exert their effects on the heart via the autonomic nervous system and via the coronary vasculature. Direct effects on the myocardium by inhaled ambient particles or their constituents require more research.
本文聚焦于心脏对环境颗粒物的反应。对来自人体研究和动物研究的现有数据进行了综述，试图在研究结果中找到共识。导致这些健康影响的病理生理机制可能很复杂，很可能有几种不同的机制共同起作用。目前的证据表明，吸入的颗粒物通过自主神经系统和冠状动脉血管系统对心脏产生影响。吸入的环境颗粒物或其成分对心肌的直接影响还需要更多研究。
