鼻窦黏液囊肿的磁共振波谱分析：脑N-乙酰天门冬氨酸的N-乙酰类似物。
MR spectroscopy in sinus mucocele: N-acetyl mimics of brain N-acetylaspartate.
作者信息
Andre E, Xu M, Yang D, Siow J K, Yeo T T, Xu Y, Lim C C T
机构信息
Department of Neuroradiology, National Neuroscience Institute, Singapore.
出版信息
AJNR Am J Neuroradiol. 2006 Nov-Dec;27(10):2210-3.
Abstract
We describe MR spectroscopy in 2 patients with frontal sinus mucoceles that showed a dominant metabolite peak at 2.0-ppm chemical shift, simulating N-acetylaspartate (NAA) of normal neuronal tissue. In vitro analysis of postsurgical mucocele samples confirmed that the signal at 2.0 ppm was arising from the methyl moiety of an N-acetyl compound. This is probably caused by N-acetylgalactosamine or N-acetylglucosamine, which are glycoproteins found in normal respiratory mucus produced by the paranasal sinus epithelium.
摘要
我们描述了2例额窦黏液囊肿患者的磁共振波谱分析，其在化学位移2.0 ppm处显示出占主导地位的代谢物峰，类似于正常神经元组织的N-乙酰天门冬氨酸（NAA）。对手术后黏液囊肿样本的体外分析证实，2.0 ppm处的信号来自一种N-乙酰化合物的甲基部分。这可能是由N-乙酰半乳糖胺或N-乙酰葡糖胺引起的，它们是鼻窦上皮产生的正常呼吸道黏液中发现的糖蛋白。
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