Mariotto Angela B, Yabroff K Robin, Feuer Eric J, De Angelis Roberta, Brown Martin
Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD 20892, USA.
Cancer Causes Control. 2006 Dec;17(10):1215-26. doi: 10.1007/s10552-006-0072-0.
This study provides projections of colorectal cancer prevalence by phases of care (initial, monitoring, and last year of life) to the year 2020 and describes the estimation method.
Cancer prevalence by phase of care was estimated from colorectal cancer incidence and survival from the Surveillance, Epidemiology, and End Results (SEER) Program data, population estimates and projections from the US Census Bureau, and all cause mortality data from the Human Mortality Life Tables. Assumptions of constant incidence and survival were used for projections from 2000 to 2020. Modeled and directly observed patient months by phase of care were compared for 1996 -1998 to provide validation of estimates.
Prevalence of colorectal cancer is estimated to increase from 1,002,786 (0.36%) patients to 1,522,348 (0.46%) patients between 2000 and 2020. The estimated number of person-months in the initial and last year of life phases of care will increase 43%, while the monitoring phase of care will increase 54%. Modeled person-months by phase of care were consistent with directly observed measures of person months by phase of care in 1996-1998.
Under assumptions of current cancer control strategies we project that colorectal cancer prevalence will increase more rapidly than the US population, largely due to the aging of the US population. This suggests that considerable resources will be needed in the future for initial, continuing and last year of life treatment of colorectal cancer patients unless notable breakthroughs in primary prevention occur in the future years.
本研究预测了到2020年按护理阶段(初始阶段、监测阶段和生命末期)划分的结直肠癌患病率,并描述了估计方法。
根据监测、流行病学和最终结果(SEER)计划数据中的结直肠癌发病率和生存率、美国人口普查局的人口估计和预测以及人类死亡率生命表中的全因死亡率数据,估计各护理阶段的癌症患病率。在2000年至2020年的预测中采用了发病率和生存率恒定的假设。比较了1996 - 1998年各护理阶段的模型化和直接观察到的患者月数,以验证估计值。
估计2000年至2020年间,结直肠癌患病率将从1,002,786例(0.36%)患者增加到1,522,348例(0.46%)患者。护理初始阶段和生命末期阶段的估计人月数将增加43%,而监测阶段将增加54%。1996 - 1998年各护理阶段的模型化人月数与直接观察到的人月数测量结果一致。
在当前癌症控制策略的假设下,我们预测结直肠癌患病率的增长将快于美国人口增长,这主要是由于美国人口老龄化。这表明,除非未来几年在一级预防方面取得显著突破,否则未来将需要大量资源用于结直肠癌患者的初始治疗、持续治疗和生命末期治疗。