猪CD1基因簇的基因组结构分析。
Analysis of the genomic structure of the porcine CD1 gene cluster.
作者信息
Eguchi-Ogawa Tomoko, Morozumi Takeya, Tanaka Maiko, Shinkai Hiroki, Okumura Naohiko, Suzuki Kohei, Awata Takashi, Uenishi Hirohide
机构信息
Animal Genome Research Program, National Institute of Agrobiological Sciences, 2-1-2 Kannondai, Tsukuba, Ibaraki 305-8602, Japan.
出版信息
Genomics. 2007 Feb;89(2):248-61. doi: 10.1016/j.ygeno.2006.10.003. Epub 2006 Nov 16.
CD1 is an MHC class I-like protein that presents lipid antigens to T cell receptors. We determined 470,187 bp of the genomic sequence encompassing the region encoding porcine CD1 genes. We identified 16 genes in this region and newly identified CD1A2, CD1B, CD1C, CD1D, and CD1E. Porcine CD1 genes were located in clusters between KIRREL and olfactory receptor (OR) genes, as observed in humans, although they were divided into two regions by a region encoding OR genes. Comparison of the genomic sequences of CD1 gene loci in pigs with other mammals showed that separation of the CD1 gene cluster by ORs was observed only in pigs. CD1A duplication in the porcine genome was estimated to have occurred after the divergence of the human and porcine. This analysis of the genomic sequence of the porcine CD1 family will contribute to our understanding of the evolution of mammalian CD1 genes.
CD1是一种与MHC I类蛋白相似的蛋白质，可将脂质抗原呈递给T细胞受体。我们测定了包含猪CD1基因编码区域的470,187 bp基因组序列。我们在该区域鉴定出16个基因，并新鉴定出CD1A2、CD1B、CD1C、CD1D和CD1E。与人类一样，猪的CD1基因位于KIRREL和嗅觉受体（OR）基因之间的簇中，尽管它们被一个编码OR基因的区域分成了两个区域。猪与其他哺乳动物CD1基因座的基因组序列比较表明，只有猪中观察到ORs将CD1基因簇分开。据估计，猪基因组中的CD1A复制发生在人和猪分化之后。对猪CD1家族基因组序列的分析将有助于我们了解哺乳动物CD1基因的进化。
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