Department of Animal Sciences, University of Florida, Gainesville, FL 32611, USA.
College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA.
Int J Mol Sci. 2017 Dec 27;19(1):68. doi: 10.3390/ijms19010068.
Invariant natural killer T (iNKT) cells are an "innate-like" T cell lineage that recognize glycolipid rather than peptide antigens by their semi-invariant T cell receptors. Because iNKT cells can stimulate an extensive array of immune responses, there is considerable interest in targeting these cells to enhance human vaccines against a wide range of microbial pathogens. However, long overlooked is the potential to harness iNKT cell antigens as vaccine adjuvants for domestic animal species that express the iNKT cell-CD1d system. In this review, we discuss the prospect of targeting porcine iNKT cells as a strategy to enhance the efficiency of swine influenza vaccines. In addition, we compare the phenotype and tissue distribution of porcine iNKT cells. Finally, we discuss the challenges that must be overcome before iNKT cell agonists can be contemplated for veterinary use in livestock.
不变自然杀伤 T(iNKT)细胞是一种“先天样”T 细胞谱系，通过其半不变 T 细胞受体识别糖脂而不是肽抗原。由于 iNKT 细胞可以刺激广泛的免疫反应，因此人们对靶向这些细胞以增强针对多种微生物病原体的人类疫苗产生了浓厚的兴趣。然而，长期以来被忽视的是利用 iNKT 细胞抗原作为表达 iNKT 细胞-CD1d 系统的家畜物种的疫苗佐剂的潜力。在这篇综述中，我们讨论了将猪 iNKT 细胞作为增强猪流感疫苗效率的策略的前景。此外，我们比较了猪 iNKT 细胞的表型和组织分布。最后，我们讨论了在考虑将 iNKT 细胞激动剂用于牲畜兽医用途之前必须克服的挑战。
