Rikihisa Yasuko
Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA.
Ann N Y Acad Sci. 2006 Oct;1078:438-45. doi: 10.1196/annals.1374.083.
Members of the family Anaplasmataceae are obligate intracellular Gram-negative bacteria that naturally infect a variety of wild and domestic animal species, the spillover of which may lead to zoonosis. I discuss new findings on members of the family Anaplasmataceae of veterinary importance and therefore, I will describe the recent findings on Neorickettsia risticii in the trematode and related Neorickettsia species. I also will review the recent progress on Aegyptianella pullorum and other Aegyptianella sp., "Candidatus Neoehrlichia mikurensis" and Anaplasma phagocytophilum strains in various hosts. The whole genome sequences of two important veterinary pathogens-Anaplasma marginale, the bovine anaplasmosis agent, and Ehrlichia (formerly Cowdria) ruminantium, the agent of heartwater of ruminants-have been published. Taken together, these advances in research of the family Anaplasmataceae in the veterinary field provide us with insights into the evolution, reservoir, and transmission of these organisms in nature and their pathogenesis in natural and accidental hosts. It is through this work that surveillance, diagnosis, preventive measures, and treatment of ehrlichioses of both animals and humans can be improved.
无形体科的成员是专性细胞内革兰氏阴性细菌，它们自然感染多种野生动物和家畜物种，其溢出可能导致人畜共患病。我将讨论兽医领域中具有重要意义的无形体科成员的新发现，因此，我将描述在吸虫中里氏新立克次体及相关新立克次体物种的最新发现。我还将回顾鸡埃及小体及其他埃及小体属、“嗜吞噬细胞无形体米库伦斯亚种”以及不同宿主中的嗜吞噬细胞无形体菌株的最新研究进展。两种重要的兽医病原体——牛无形体病病原体边缘无形体和反刍动物心水病病原体反刍兽埃立克体（原考德里氏体）的全基因组序列已公布。总的来说，无形体科在兽医领域的这些研究进展为我们提供了关于这些生物体在自然界中的进化、宿主和传播以及它们在自然宿主和意外宿主中的发病机制的见解。正是通过这项工作，可以改进动物和人类埃立克体病的监测、诊断、预防措施和治疗。
