Baird John D, Arroyo Luis G
Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1.
Can Vet J. 2013 Jun;54(6):565-72.
In the summer of 1924 Dr. Frank W. Schofield conducted investigations into an endemic disease of horses in the Kent and Essex counties of Ontario. According to farmers in these counties the disease had existed in this region for at least 50 years previously. The clinical, pathological, histopathological, and epidemiological findings outlined in Schofield's detailed report strongly suggest that this endemic disease was what was designated in 1979 as "Potomac horse fever" (PHF). This assumption is further substantiated by transmission experiments involving horses and laboratory animals that were conducted by Schofield utilizing horse feces, whole blood, and mayflies. The aim of this paper is to present Schofield's detailed investigations and findings and to compare these with PHF research conducted from 1979 to 2010 that ultimately led to the discovery of Neorickettsia risticii as the etiological agent and to elucidation of the organism's complex life cycle.
1924年夏天，弗兰克·W·斯科菲尔德博士对安大略省肯特郡和埃塞克斯郡马匹的一种地方病展开了调查。据这些郡的农民称，这种疾病在该地区至少已存在50年。斯科菲尔德详细报告中概述的临床、病理、组织病理和流行病学调查结果有力地表明，这种地方病就是1979年被认定为“波托马克马热”（PHF）的疾病。斯科菲尔德利用马粪、全血和蜉蝣对马匹及实验动物进行的传播实验进一步证实了这一假设。本文旨在呈现斯科菲尔德的详细调查及结果，并将其与1979年至2010年开展的PHF研究进行比较，这些研究最终发现了里氏新立克次体作为病原体，并阐明了该生物体复杂的生命周期。
