Reginato Mauricio J, Muthuswamy Senthil K
Department of Biochemistry and Molecular Biology, College of Medicine, Drexel University, 245 N. 15th Street, Philadelphia, PA 19102, USA.
J Mammary Gland Biol Neoplasia. 2006 Oct;11(3-4):205-11. doi: 10.1007/s10911-006-9030-4.
The lumens present in ductal structures are required for transport of fluids and air. Studies in model organisms and cells in culture suggest that lumens can be generated by multiple mechanisms including apoptosis of centrally located cells, and re-modeling of epithelia. Several studies point to a role for apoptosis during lumen formation in the mammary ducts. However, a role for other mechanisms during lumen formation in the mammary ducts is largely unexplored. Understanding how lumens are formed and maintained free of cells is of clinical importance because filling of the luminal space is associated with cancer and inflammation. Thus, further investigation can lead to new diagnostic and therapeutic opportunities.
导管结构中的管腔对于液体和空气的运输是必需的。对模式生物和培养细胞的研究表明，管腔可以通过多种机制形成，包括位于中心位置的细胞凋亡以及上皮细胞重塑。多项研究指出凋亡在乳腺导管管腔形成过程中发挥作用。然而，乳腺导管管腔形成过程中其他机制的作用在很大程度上尚未得到探索。了解管腔如何形成并保持无细胞状态具有临床重要性，因为管腔空间的填充与癌症和炎症相关。因此，进一步的研究可能带来新的诊断和治疗机会。
