Wiers Reinout W, Bartholow Bruce D, van den Wildenberg Esther, Thush Carolien, Engels Rutger C M E, Sher Kenneth J, Grenard Jerry, Ames Susan L, Stacy Alan W
Experimental Psychology, Maastricht University, Maastricht, The Netherlands.
Pharmacol Biochem Behav. 2007 Feb;86(2):263-83. doi: 10.1016/j.pbb.2006.09.021. Epub 2006 Nov 20.
This paper presents a review and a model of the development of addictive behaviors in (human) adolescents, with a focus on alcohol. The model proposes that addictive behaviors develop as the result of an imbalance between two systems: an appetitive, approach-oriented system that becomes sensitized with repeated alcohol use and a regulatory executive system that is not fully developed and that is compromised by exposure to alcohol. Self-regulation critically depends on two factors: ability and motivation to regulate the appetitive response tendency. The motivational aspect is often still weak in heavy drinking adolescents, who typically do not recognize their drinking as problematic. Motivation to regulate use often develops only years later, after the individual has encountered serious alcohol-related problems. Unfortunately, at that point behavioral change becomes harder due to several neurocognitive adaptations that result from heavy drinking. As we document, there is preliminary support for the central elements of the model (appetitive motivation vs. self-regulation), but there is a paucity of research directly addressing these mechanisms in human adolescents. Further, we emphasize that adolescent alcohol use primarily takes place in a social context, and that therefore studies should not solely focus on intra-individual factors predicting substance use and misuse but also on interpersonal social factors. Finally, we discuss implications of the model for interventions.
本文对(人类)青少年成瘾行为的发展进行了综述并提出了一个模型,重点关注酒精。该模型提出,成瘾行为的发展是由于两个系统之间的失衡所致:一个是通过反复饮酒而变得敏感的欲望驱动、趋近导向系统,另一个是尚未完全发育且因接触酒精而受损的调节执行系统。自我调节关键取决于两个因素:调节欲望反应倾向的能力和动机。在重度饮酒的青少年中,动机方面往往仍然薄弱,他们通常不认为自己的饮酒存在问题。调节饮酒的动机往往要在数年之后才会发展起来,此时个体已经遭遇了严重的与酒精相关的问题。不幸的是,到那时,由于重度饮酒导致的几种神经认知适应,行为改变变得更加困难。正如我们所记录的,该模型的核心要素(欲望动机与自我调节)有初步的支持证据,但直接针对人类青少年这些机制的研究却很少。此外,我们强调青少年饮酒主要发生在社会环境中,因此研究不应仅仅关注预测物质使用和滥用的个体内部因素,还应关注人际社会因素。最后,我们讨论了该模型对干预措施的启示。