Battillo Daniel J, Malin Steven K
Department of Kinesiology and Health, Rutgers University, New Brunswick, NJ 08901, USA.
Department of Kinesiology, University of Virginia, Charlottesville, VA 22903, USA.
Metabolites. 2023 Jan 17;13(2):137. doi: 10.3390/metabo13020137.
Prediabetes raises cardiovascular disease risk, in part through elevated aortic waveforms. While insulin is a vasodilatory hormone, the gut hormone relation to aortic waveforms is less clear. We hypothesized that exercise, independent of intensity, would favor aortic waveforms in relation to gut hormones. Older adults (61.3 ± 1.5 yr; 33.2 ± 1.1 kg/m) with prediabetes (ADA criteria) were randomized to undertake 60 min of work-matched continuous (CONT, = 14) or interval (INT, = 14) exercise for 2 wks. During a 180 min 75-g OGTT, a number of aortic waveforms (applanation tonometry) were assessed: the augmentation pressure (AP) and index (AIx75), brachial (bBP) and central blood pressure (cBP), pulse pressure (bPP and cPP), pulse pressure amplification (PPA), and forward (Pf) and backward pressure (Pb) waveforms. Acylated-ghrelin (AG), des-acylated ghrelin (dAG), GIP, and GLP-1 were measured, and correlations were co-varied for insulin. Independent of intensity, exercise increased VOpeak ( = 0.01) and PPA ( = 0.01) and reduced weight ( < 0.01), as well as AP ( = 0.02) and AIx75 ( < 0.01). CONT lowered bSBP ( < 0.02) and bDBP ( < 0.02) tAUC more than INT. There were decreases dAG related to Pb (r = 0.47, = 0.03), cPP (r = 0.48, = 0.02), and AP (r = 0.46, = 0.02). Declines in AG tAUC correlated with lower Pb (r = 0.47, = 0.03) and cPP (r = 0.49, = 0.02) were also found. GLP-1 was reduced associated with lowered AP (r = 0.49, = 0.02). Thus, while CONT exercise favored blood pressure, both intensities of exercise improved aortic waveforms in relation to gut hormones after controlling for insulin.
糖尿病前期会增加心血管疾病风险，部分原因是主动脉波形升高。虽然胰岛素是一种血管舒张激素，但肠道激素与主动脉波形的关系尚不清楚。我们假设，运动（与强度无关）会有利于改善与肠道激素相关的主动脉波形。将患有糖尿病前期（符合美国糖尿病协会标准）的老年人（61.3±1.5岁；体重指数33.2±1.1kg/m²）随机分为两组，一组进行60分钟与工作强度匹配的持续运动（CONT组，n = 14），另一组进行间歇运动（INT组，n = 14），为期2周。在180分钟的75克口服葡萄糖耐量试验（OGTT）期间，评估了多个主动脉波形（应用压平式眼压计）：增强压（AP）和增强指数（AIx75）、肱动脉血压（bBP）和中心血压（cBP）、脉压（bPP和cPP）、脉压放大（PPA）以及正向（Pf）和反向压力（Pb）波形。测量了酰基化胃饥饿素（AG）、去酰基化胃饥饿素（dAG）、葡萄糖依赖性促胰岛素多肽（GIP）和胰高血糖素样肽-1（GLP-1），并对胰岛素进行协变量校正后计算相关性。与运动强度无关，运动增加了峰值摄氧量（P<0.01）和脉压放大（P<0.01），降低了体重（P<0.01）、增强压（P = 0.02）和增强指数（AIx75，P<0.01）。CONT组降低肱动脉收缩压（bSBP）（P<0.02）和舒张压（bDBP）（P<0.02）的时间-曲线下面积（tAUC）比INT组更多。去酰基化胃饥饿素（dAG）与反向压力（Pb）（r = 0.47，P = 0.03）、中心脉压（cPP）（r = 0.48，P = 0.02）和增强压（AP）（r = 0.46，P = 0.02）呈负相关。酰基化胃饥饿素（AG）的tAUC下降与较低的反向压力（Pb）（r = 0.47，P = 0.03）和中心脉压（cPP）（r = 0.49，P = 0.02）也相关。胰高血糖素样肽-1（GLP-1）降低与增强压降低相关（r = 0.49，P = 0.02）。因此，虽然CONT组运动对血压更有益，但在对胰岛素进行校正后，两种运动强度均改善了与肠道激素相关的主动脉波形。
